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Clinical Study of rhTSH in the Treatment of Patients With Thyroid Cancer After Resection of Stage I/II

2019-10-28 13:56:49 | BioPortfolio

Summary

Dose-increasing tolerance, pharmacokinetics, and iodine uptake effects of recombinant human thyroid stimulating hormone in patients after thyroidectomy

Description

This phase 1 and 2 study of rhTSH, To observe the safety and tolerability characteristics of different doses of rhTSH in patients after thyroidectomy, and to observe the dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) that may occur in the set dose group.The study is a Non-randomized, open, one-arm study.

Study Design

Conditions

Differentiated Thyroid Cancer

Intervention

Recombinant Human Thyroid Stimulating Hormone for Injection

Location

Peking Union Medical College Hospital
Beijing
Beijing
China

Status

Recruiting

Source

Suzhou Zelgen Biopharmaceuticals Co.,Ltd

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-28T13:56:49-0400

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Medical and Biotech [MESH] Definitions

Autoantibodies that bind to the thyroid-stimulating hormone (TSH) receptor (RECEPTORS, THYROTROPIN) on thyroid epithelial cells. The autoantibodies mimic TSH causing an unregulated production of thyroid hormones characteristic of GRAVES DISEASE.

A common form of hyperthyroidism with a diffuse hyperplastic GOITER. It is an autoimmune disorder that produces antibodies against the THYROID STIMULATING HORMONE RECEPTOR. These autoantibodies activate the TSH receptor, thereby stimulating the THYROID GLAND and hypersecretion of THYROID HORMONES. These autoantibodies can also affect the eyes (GRAVES OPHTHALMOPATHY) and the skin (Graves dermopathy).

A highly purified recombinant glycoprotein form of human THYROID-STIMULATING HORMONE, produced by recombinant DNA technology comprising two non-covalently linked subunits, an alpha subunit of 92 amino acid residues containing two N-linked glycosylation sites, and a beta subunit of 118 residues containing one N-linked glycosylation site. The amino acid sequence of thyrotropin alfa is identical to that of human pituitary thyroid stimulating hormone.

An inherited autosomal recessive trait, characterized by peripheral resistance to THYROID HORMONES and the resulting elevation in serum levels of THYROXINE and TRIIODOTHYRONINE. This syndrome is caused by mutations of gene THRB encoding the THYROID HORMONE RECEPTORS BETA in target cells. HYPOTHYROIDISM in these patients is partly overcome by the increased thyroid hormone levels.

A condition characterized by the presence of rudimentary THYROID tissue at the base of the TONGUE. It is due to failed embryonic development and migration of thyroid tissue to its normal location. The lingual thyroid usually cannot maintain adequate hormone production thereby resulting in HYPOTHYROIDISM.

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