Track topics on Twitter Track topics that are important to you
This study will evaluate the safety, tolerability and pharmacokinetics (PK) of escalating single-and multiple-oral doses of ZSP0678 on fasted condition, and characterize PK of ZSP0678 on an empty stomach (fasted condition) and following a high fat, high calorie meal (fed condition) in a 2-period, 2-sequence manner. The study will be conducted in 3 parts (Ascending single dose, multiple dose and food effect). Participants will receive either ZSP0678 or placebo .
ZSP0678-10mg, ZSP0678-30mg, ZSP0678-60mg, ZSP0678-120mg, ZSP0678-180mg, ZSP0678-240mg, ZSP0678-320mg, ZSP0678, ZSP0678-Dose 1, ZSP0678-Dose 2, ZSP0678-Dose 3, ZSP0678 Placebo
Beijing Friendship Hospital Affiliated to Capital Medical Universit
Not yet recruiting
Guangdong Raynovent Biotech Co., Ltd
Published on BioPortfolio: 2019-10-28T13:56:50-0400
The purpose of this clinical study is to evaluate and compare the efficacy and safety of Fimasartan (60mg / 120mg) with Candesartan(8mg) in patients with mild to moderate hypertension.
Study to compare PK of a new 120mg tablet with two 60mg tablets. This is required because we plan to have only single tablets administered in the later phase clinical trials but we have n...
This Study compares two ZD4054 doses (10mg and 30mg) with a placebo and a positive control to look at ZD4054's effect on the ECG of Healthy Volunteer
To evaluate the efficacy, dose response and safety of four doses of GSK2190915 in tablet form (10mg, 30mg, 100mg and 300mg) administered once daily, over 8 weeks compared with placebo in a...
Brief summary: This is a phase II study to investigate the safety, preliminary efficacy and pharmacokinetics of AD-35 tablet in patients with mild to moderate Alzheimer's Disease. This stu...
The objective of this systematic review was to assess the analgesic efficacy of duloxetine (DLX) for fibromyalgia (FM) and find which dosage between 60mg/d DLX and 120mg/d DLX was more suitable for cl...
We assessed the effect of Sorafenib loaded polyamidoamine (PAMAM)-dendrimer on liver fibrosis induced by bile duct ligation (BDL). Male Wistar rats were divided into nine groups: intact, sham, DMSO+BD...
Edoxaban treatment for stroke prevention in atrial fibrillation (AF) has mainly been investigated in randomized controlled trials, and data reflecting clinical practice are limited. We ascertained the...
Psychological stress and excess glucocorticoids are associated with metabolic and cardiovascular diseases. Glucocorticoids primarily act through mineralocorticoid (MR) and glucocorticoid receptors (GR...
An over activation of GPCR mediated Gαq dependent signaling pathway is widely associated with the development of cardiovascular abnormalities. The objective of study was to evaluate the effects of (1...
Within medicine, nutrition (the study of food and the effect of its components on the body) has many different roles. Appropriate nutrition can help prevent certain diseases, or treat others. In critically ill patients, artificial feeding by tubes need t...
Food is any substance consumed to provide nutritional support for the body. It is usually of plant or animal origin, and contains essential nutrients, such as carbohydrates, fats, proteins, vitamins, or minerals. The substance is ingested by an organism ...