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Pemetrexed and Carboplatin With or Without Anlotinib Hydrochloride for Osimertinib-resistant Non-squamous NSCLC

2019-10-28 13:56:55 | BioPortfolio

Summary

Evaluate the efficacy and safety of Anlotinib Hydrochloride in combination with Pemetrexed and Carboplatin versus Pemetrexed and Carboplatin for advanced or locally-advanced Osimertinib-resistant non-squamous non-small cell lung cancer.

Description

Anlotinib Hydrochloride in combination with Pemetrexed and Carboplatin use 4 cycles,then continue pem and anlotinib until PD

Pemetrexed and Carboplatin use 4 cycles,then continue pem until PD

TO see the different of PFS and OS and safety between the two group

Study Design

Conditions

NSCLC Stage IV

Intervention

Pemetrexed, Carboplatin, Anlotinib

Location

Cancer hospital Fudan University
Shanghai
Shanghai
China
200032

Status

Not yet recruiting

Source

Fudan University

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-28T13:56:55-0400

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Medical and Biotech [MESH] Definitions

An organoplatinum compound that possesses antineoplastic activity.

The stage in the first meiotic prophase, following ZYGOTENE STAGE, when CROSSING OVER between homologous CHROMOSOMES begins.

The process of TOOTH formation. It is divided into several stages including: the dental lamina stage, the bud stage, the cap stage, and the bell stage. Odontogenesis includes the production of tooth enamel (AMELOGENESIS), dentin (DENTINOGENESIS), and dental cementum (CEMENTOGENESIS).

A guanine-derived ANTINEOPLASTIC AGENT that functions as a NUCLEIC ACID SYNTHESIS INHIBITOR through its binding to, and inhibition of, THYMIDYLATE SYNTHASE.

The earliest developmental stage of a fertilized ovum (ZYGOTE) during which there are several mitotic divisions within the ZONA PELLUCIDA. Each cleavage or segmentation yields two BLASTOMERES of about half size of the parent cell. This cleavage stage generally covers the period up to 16-cell MORULA.

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