Early Conversion of Dasatinib in CML-CP Patients

2019-10-28 13:57:11 | BioPortfolio


Chronic myeloid leukemia (CML) is a malignant disease of acquired hematopoietic stem cells. The BCR-ABL fusion gene is the pathogenic basis of CML. Tyrosine kinase inhibitors (TKIs) are targeted drugs for this fusion protein. With the wide clinical application of TKIs, the efficacy of CML patients has been greatly improved. However, there are still a significant number of patients who have poor response to the first generation of TKI drugs, imatinib, most of them have early molecular response failures (BCR-ABL(IS)>10% at 3 or 6 months) ,which means lower rates of molecular response, increased risk of progression, and higher overall survival. For them, the early conversion of dasatinib might be a better choice.

Study Design


Validity and Safety


Dasatinib 100 MG




Enrolling by invitation


Nanfang Hospital of Southern Medical University

Results (where available)

View Results


Published on BioPortfolio: 2019-10-28T13:57:11-0400

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