A Multi-center RCT Trial on Prognosis of Patients With Anticoagulation and DAPT Therapy After LAAC

2019-10-28 13:57:15 | BioPortfolio


The objective of this study is to assess the different dosage of rivaroxaban application versus dual antiplatelet therapy for prevention of device-related-thrombus in patients undergoing left atrial appendage closure using the WATCHMAN device.


Transcatheter left atrial appendage occlusion(LAAO) has emerged as an effective alternative for preventing thromboembolic events in patients with nonvalvular atrial fibrillation. The contemporary strategy for post-implantation antithrombotic medication therapy derived from several initial industrialized authoritative researches, demonstrated as 45days for anticoagulation and prolonged DOAC for 6 months. In spite of the increasing experience of operators and arrival of new technologies, the rates of DRT still maintained. Therefore, whether altered medication therapy post-implantation attracted overwide attention. Nowadays, new oral anticoagulation such as rivaroxaban, dabigatran has evolved empirically and successively has been applied for days-weeks anticoagulation therapy following LAAO ,yet, the specific recommended dosage remained unclear.

Therefore, the objective of the study is to compare the effects of different dosage of rivaroxaban for short-term(3months) anticoagulation therapy versus DAPT on the prevention of device thrombusis following transcatheter LAAO.

Study Design


Left Atrial Appendage Thrombosis


Rivaroxaban, Rivaroxaban, DAPT


Not yet recruiting


Shanghai Zhongshan Hospital

Results (where available)

View Results


Published on BioPortfolio: 2019-10-28T13:57:15-0400

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