The Effect of Naproxen on the Pharmacokinetic Profile of LC350189 in Healthy Adults

2019-10-30 14:03:43 | BioPortfolio


This is a Phase 1, open-label, fixed-sequence, 3-period, 2-way drug interaction study designed to assess the pharmacokinetics, pharmacodynamics, safety, and tolerability of LC350189 and Naproxen when administered alone and in combination in healthy subjects.

Study Design




Xanthine Oxidase Inhibitor, nonsteroidal anti-inflammatory drug


Not yet recruiting


LG Chem

Results (where available)

View Results


Published on BioPortfolio: 2019-10-30T14:03:43-0400

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A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.

A xanthine oxidase inhibitor.

An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.

A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.

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