Topics

The Effect of Naproxen on the Pharmacokinetic Profile of LC350189 in Healthy Adults

2019-10-30 14:03:43 | BioPortfolio

Summary

This is a Phase 1, open-label, fixed-sequence, 3-period, 2-way drug interaction study designed to assess the pharmacokinetics, pharmacodynamics, safety, and tolerability of LC350189 and Naproxen when administered alone and in combination in healthy subjects.

Study Design

Conditions

Gout

Intervention

Xanthine Oxidase Inhibitor, nonsteroidal anti-inflammatory drug

Status

Not yet recruiting

Source

LG Chem

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-30T14:03:43-0400

Clinical Trials [2801 Associated Clinical Trials listed on BioPortfolio]

A Study to Assess Efficay and Safety of LC350189 Different Doses in Gout Patients With Hyperuricemia

The aim of this 12-week randomized multicenter double-blind double-dummy parallel group placebo and active comparator-controlled dose finding study is to assess the efficacy and safety of ...

Post-Authorisation Safety Study of Lesinurad

Non-interventional population-based prospective cohort study in multiple databases comparing patients with gout who initiate lesinurad in combination with an existing xanthine oxidase inhi...

The Effect of Colchicine on the Pharmacokinetic Profile of LC350189 in Healthy Aldults.

This is a Phase 1, open-label, fixed-sequence, 3-period, 2-way drug interaction study designed to assess the PK, PD, safety, and tolerability of LC350189 and colchicine when administered a...

Zurig (Febuxostat) 40mg Efficacy and Safety Trial

Febuxostat is a potent, nonpurine, selective inhibitor of Xanthine oxidase that exhibits antihyperuricemic activity by reducing the formation of uric acid. The investigators conducted an i...

Uric Acid Metabolism, Endothelial Function and Oxidative Stress in Vegans and Omnivores.

50 vegans and 50 omnivores will be recruited at the Erasme Hospital, Brussels. Hypothesis - Relative induced-hyperuricemia by the vegan diet is not associated with impaired ...

PubMed Articles [19794 Associated PubMed Articles listed on BioPortfolio]

Selective hypersensitivity to a single nonsteroidal anti-inflammatory drug.

The aim of the study was to explore the frequency and the clinical and diagnostic characteristics of a single nonsteroidal anti-inflammatory drug-induced hypersensitivity (SNIUAA) subgroup.

Targeting the subpocket in xanthine oxidase: Design, synthesis, and biological evaluation of 2-4-alkoxy-3-(1H-tetrazol-1-yl) phenyl-6-oxo-1,6-dihydropyrimidine-5-carboxylic acid derivatives.

Xanthine oxidase is an important target for the treatment of hyperuricemia, gout and other related diseases. Analysis of the high-resolution structure of xanthine oxidase with febuxostat identified th...

Nimesulide analogues: From anti-inflammatory to antitumor agents.

Nimesulide is a nonsteroidal anti-inflammatory drug possessing analgesic and antipyretic properties. This drug is considered a selective cyclooxygenase-2 (COX-2) inhibitor and, more recently, has been...

Mechanistic approach towards interaction of newly synthesized Hesperidin derivatives against xanthine oxidase.

Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and m...

NADPH oxidase is a primary target for antioxidant effects by inorganic nitrite in lipopolysaccharide-induced oxidative stress in mice and in macrophage cells.

Nicotinamide adenine dinucleotide phosphate (NADPH) oxidase and oxidative stress is usually considered as an important factor to the pathogenesis of various diseases. Inorganic nitrite, previously vie...

Medical and Biotech [MESH] Definitions

A thiazole derivative and inhibitor of XANTHINE OXIDASE that is used for the treatment of HYPERURICEMIA in patients with chronic GOUT.

A uricosuric drug that is used to reduce the serum urate levels in gout therapy. It lacks anti-inflammatory, analgesic, and diuretic properties.

A xanthine oxidase inhibitor.

An oxidation product, via XANTHINE OXIDASE, of oxypurines such as XANTHINE and HYPOXANTHINE. It is the final oxidation product of purine catabolism in humans and primates, whereas in most other mammals URATE OXIDASE further oxidizes it to ALLANTOIN.

A non-steroidal anti-inflammatory agent with analgesic, anti-inflammatory, and antipyretic properties. It is an inhibitor of cyclooxygenase.

More From BioPortfolio on "The Effect of Naproxen on the Pharmacokinetic Profile of LC350189 in Healthy Adults"

Quick Search

Relevant Topics

Drug Discovery
Clinical Approvals Clinical Trials Drug Approvals Drug Delivery Drug Discovery Generics Drugs Prescription Drugs In the fields of medicine, biotechnology and pharmacology, drug discovery is the process by which drugs are dis...

Rheumatology
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...


Searches Linking to this Trial