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Extracorporeal membrane oxygenation (ECMO) is widely used in the salvage treatment of critical acute respiratory distress syndrome (ARDS). However, reduce lung injury, accelerate lung recovery, shorten VV-ECMO support time and decrease complications during the treatment needs further study. By changing the body position of ARDS patients, prone position can increase the dorsal ventilation of the lung and improve the ventilation/blood flow ratio of the lung, so as to improve oxygenation. Previous multicenter studies have proved that prone position can significantly reduce the mortality of patients with moderate and severe ARDS. However, patients with severe ARDS rescue by VV-ECMO is rarely combined with prone position. On the one hand, with the support of ECMO, the patients oxygenation will be significantly improved, and they will no longer need the assist of prone position. On the other hand, ECMO cannula brings some challenges to the implementation of prone position. At present, only a few cohort studies have reported that VV-ECMO combined with prone position could improve the oxygenation index and respiratory system compliance during the late period of treatment. This study aims to evaluate whether early prone position could reduce VV-ECMO duration time, so as to reduce the occurrence of ECMO-related complications, which may ultimately affect the prognosis of ARDS patients treated by ECMO.
Respiratory Distress Syndrome, Adult
Prone positon, Supine positon
Beijing Chao-Yang Hospital
Not yet recruiting
Beijing Chao Yang Hospital
Published on BioPortfolio: 2019-10-30T14:03:44-0400
The purpose of this study is to determine whether prone positioning is effective in improving survival in patients affected by acute respiratory distress syndrome (ARDS).
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