Effects of Acute Hypobaric Hypoxia Exposure on Neurocognitive Performance of Pre-hospital Emergency Service Providers

2019-10-29 14:36:39 | BioPortfolio


The study aims to evaluate the effects of acute hypobaric hypoxia on cognitive performance (H0: cognitive performance at 200 meters above sea level (asl) = cognitive performance at 3000 meters above sea level = cognitive performance at 5000 meters above sea level).

Before participating in the study, each participant will respond to a questionnaire related to high altitude exposure (prior 3 months), as well as inclusion/exclusion criteria evaluation.

On day 0, after the interview and signed informed consent, the participant will undergo a medical examination that will include a general objective examination. Participants will participate in a training on the emergency and safety procedures of the hypobaric hypoxia facility, as well as a refresh on cardiopulmonary resuscitation procedure.

During the following two days (day 1 and 2) the study protocol will be executed (one test per day). The study protocol envisages:

- a basal cognitive test battery

- blind ascent in the hypobaric chamber to simulated altitude

- cognitive test battery

- 5 minutes of recorded chest compressions on dummies

- cognitive test battery

- blind descent in the hypobaric chamber.

During the stay in the hypobaric hypoxic facility, each participant will be monitored in real time with the Equivital© medical monitoring device.

Before and after the stay in the hypobaric hypoxic facility, a saliva sample will be collected, and psychological tests administered.

Study Design


Hypobaric Hypoxia


Altitude exposure in climate chamber


Eurac Research, Institute of Mountain Emergency Medicine




Institute of Mountain Emergency Medicine

Results (where available)

View Results


Published on BioPortfolio: 2019-10-29T14:36:39-0400

Clinical Trials [1008 Associated Clinical Trials listed on BioPortfolio]

Effects of Mild Hypobaric Hypoxia on Sleep and Post-sleep Performance

Hypobaric hypoxia (decreased oxygen supply to body tissues due to low atmospheric pressure) caused by exposure to high altitude disrupts sleep. Sleep deprivation is associated with degrad...

The Altitude Inflammatory Bowel Disease Study

This is a prospective, controlled and observational study. Participants underwent a 3-hour exposure to hypoxic conditions simulating an altitude of 4,000 meters above sea level (m.a.s.l.) ...

Oxygen Transport in Normobaric vs. Hypobaric Hypoxia

1) Oxygen Transport in Normobaric versus Hypobaric Hypoxia. 2) The purpose of this study is to examine acute responses in arterial and muscle tissue oxygenation during incremental exercise...

Analysis of Protein and Emotional Alterations During and After Hypobaric Hypoxia

This study analyses both Protein Expression and emotional alterations during hypobaric hypoxia in volunteers of different groups.

Physiological Adaptations to Simulated Intermittent Altitude on Human Health and Performance

The investigators expect to find that different intensity and altitude exposure levels will show what kind of intermittent exposure protocol is more beneficial to athletes and healthy indi...

PubMed Articles [8140 Associated PubMed Articles listed on BioPortfolio]

Influences of hypobaric hypoxia on skin blood flow and sweating responses during exercise in neutral and hot environments.

Exposure to hot environments augments cutaneous vasodilation and sweating during exercise compared to these responses in cooler environments. The effects of hypobaric hypoxia on these responses are le...

Effect of chronic intermittent hypobaric hypoxia on heart rate variability in conscious rats.

To examine the effect of chronic intermittent hypobaric hypoxia (CIHH) on heart rate variability (HRV), male adult Sprague-Dawley rats were exposed to hypoxia (oxygen 11.1%) in a hypobaric chamber for...

Characterizing the influence of chronic hypobaric hypoxia on diaphragmatic myofilament contractile function and phosphorylation in high-altitude deer mice and low-altitude white-footed mice.

Deer mice, Peromyscusmaniculatus, live at high altitudes where limited O represents a challenge to maintaining oxygen delivery to tissues. Previous work has demonstrated that hypoxia acclimation of de...

The regulation of catecholamine release from the adrenal medulla is altered in deer mice () native to high altitudes.

High-altitude natives have evolved to overcome environmental hypoxia and provide a compelling system to understand physiological function during reductions in oxygen availability. The sympathoadrenal ...

Emergence of AnnexinVpos CD31neg CD42blow/neg extracellular vesicles in plasma of humans at extreme altitude.

Hypobaric hypoxia has been reported to cause endothelial cell and platelet dysfunction implicated in the formation of microvascular lesions, and in its extremes may contribute to vascular leakage in h...

Medical and Biotech [MESH] Definitions

A type of climate characterized by insufficient moisture to support appreciable plant life. It is a climate of extreme aridity, usually of extreme heat, and of negligible rainfall. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

Any significant change in measures of climate (such as temperature, precipitation, or wind) lasting for an extended period (decades or longer). It may result from natural factors such as changes in the sun's intensity, natural processes within the climate system such as changes in ocean circulation, or human activities.

Dioxygenase enzymes that specifically hydroxylate a PROLINE residue on the HYPOXIA-INDUCIBLE FACTOR 1, ALPHA SUBUNIT. They are OXYGEN-dependent enzymes that play an important role in mediating cellular adaptive responses to HYPOXIA.

A climate characterized by COLD TEMPERATURE for a majority of the time during the year.

A climate which is typical of equatorial and tropical regions, i.e., one with continually high temperatures with considerable precipitation, at least during part of the year. (McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)

More From BioPortfolio on "Effects of Acute Hypobaric Hypoxia Exposure on Neurocognitive Performance of Pre-hospital Emergency Service Providers"

Quick Search

Searches Linking to this Trial