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Testicular Function After Testicular Torsion

2019-10-29 14:36:44 | BioPortfolio

Summary

The purpose of this study is to evaluate testicular function measured as testosterone level and semen quality.

Description

Men having undergone surgery for testicular torsion between 01.01.2003 - 12.31.2012 will receive a invitation to participate in this study. It is expected that 110 patients can be identified and about 65% of them will participate. These men will undergo a andrological evaluation, deliver a semen sample, have a blood sample taken and undergo a testicular ultrasound.

Control group:

Men attending the fertility counseling at Herlev hospital will be offered participation in this study. The fertility counseling demands that men who contact the clinic have never had their sperm analyzed, have not tried to get pregnant with their partner for more than a year and that they have no prior knowledge of their fertility.

Primary endpoint:

Semen quality measured as sperm concentration Total testosterone level

Secondary endpoint:

Semen parameters

- Volume

- Concentration

- Motility

- Morphology

- MAR test

Hormones

- FSH

- LH

- PRL

- Testosterone

- Estradiol

- Inhibin B

- SHBG

Data points:

- Paternity

- Time to pregnancy

- Partner (yes/no)

- Any fertility treatment?

- Pain? (VAS score)

- Symptoms of testesterone deficiency symptoms

- Andrological evaluation

- Testicular ultrasound

- Testicular torsion events in the family

- Date of surgery

- Date of follow up meeting

- Surgery details

Study Design

Conditions

Testicular Torsion

Status

Not yet recruiting

Source

Herlev and Gentofte Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-29T14:36:44-0400

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Medical and Biotech [MESH] Definitions

The twisting of the SPERMATIC CORD due to an anatomical abnormality that left the TESTIS mobile and dangling in the SCROTUM. The initial effect of testicular torsion is obstruction of venous return. Depending on the duration and degree of cord rotation, testicular symptoms range from EDEMA to interrupted arterial flow and testicular pain. If blood flow to testis is absent for 4 to 6 h, SPERMATOGENESIS may be permanently lost.

A surgical procedure in which an undescended testicle is sutured inside the SCROTUM in male infants or children to correct CRYPTORCHIDISM. Orchiopexy is also performed to treat TESTICULAR TORSION in adults and adolescents.

A cystic dilation of the EPIDIDYMIS, usually in the head portion (caput epididymis). The cyst fluid contains dead SPERMATOZOA and can be easily differentiated from TESTICULAR HYDROCELE and other testicular lesions.

A condition characterized by the dilated tortuous veins of the SPERMATIC CORD with a marked left-sided predominance. Adverse effect on male fertility occurs when varicocele leads to an increased scrotal (and testicular) temperature and reduced testicular volume.

Tumors or cancer of the TESTIS. Germ cell tumors (GERMINOMA) of the testis constitute 95% of all testicular neoplasms.

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