Evaluation of [18F]APN-1607 PET Uptake in Alzheimer's Disease Patients Compared With Healthy Subjects

2019-10-31 14:29:40 | BioPortfolio


The overall objective of this study is to compare the overall pattern of [18F]APN-1607 uptake in subjects with MDAD, subjects with AD dementia, and healthy subjects.


The overall objective of this study is to compare the overall pattern of [18F]APN-1607 uptake in subjects with MDAD, subjects with AD dementia, and healthy subjects.

The specific objectives are:

- To expand the safety and tolerability profile for the administration of [18F]APN-1607 and PET scanning.

- To assess regional patterns of [18F]APN-1607 uptake.

- To determine the Braak stage equivalent reflected by [18F]APN-1607 uptake patterns.

- To evaluate the relationship between regional measures of [18F]APN-1607 uptake and demographic characteristics, eg, age and gender; biological characteristics, eg, apolipoprotein E epsilon 4 (APOE4) carrier status and measures of Aβ burden; and clinical characteristics, eg, measurements of AD disease severity, such as National Institute on Aging and Alzheimer's Association (NIA-AA) diagnosis, Mini-mental Status Exam (MMSE) score, and Alzheimer's Disease Assessment Scale-cognitive subscale (ADAScog).

Study Design


Alzheimer's Disease




New Haven
United States




Aprinoia Therapeutics Inc.

Results (where available)

View Results


Published on BioPortfolio: 2019-10-31T14:29:40-0400

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