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Effects of Exercise on Glymphatic Functioning and Neurobehavioral Correlates in Parkinson's Disease

2019-10-31 14:29:43 | BioPortfolio

Summary

This study is designed to measure the change in patients diagnosed with Parkinson's disease (PD) before, during and after a 12 week exercise program.The focus of this study is the glymphatic system. The glymphatic system is a recentlydiscovered novel waste clearance pathway, in patients with Parkinson's Disease (PD).The glymphatic system acts as a waste-clearance system in the brain of vertebrate animals.The glymphatic system has been proposed in which new clearance pathways involving communication between paravascular spaces, interstitial fluid, and ultimately meningeal and dural lymphatic vessels exists, and we have provided evidence that this system may be dysfunctional in patients with Parkinson's disease with cognitive disorders. Early research suggest glymphatic function increases following exercise, this response is believed to clear beta-amyloid in the brain and may mediate the neurobehavioral response to exercise in PD.

This study will use cognitive exams, neurological exams as well as specialized imaging to record data points and evaluate the glymphatic function after exercise.

Study Design

Conditions

Parkinson's Disease and Parkinsonism

Intervention

Exercise--Rock Steady Boxing class

Location

Vanderbilt University Medical Center
Nashville
Tennessee
United States
37212

Status

Not yet recruiting

Source

Vanderbilt University Medical Center

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-10-31T14:29:43-0400

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Medical and Biotech [MESH] Definitions

A group of disorders which feature impaired motor control characterized by bradykinesia, MUSCLE RIGIDITY; TREMOR; and postural instability. Parkinsonian diseases are generally divided into primary parkinsonism (see PARKINSON DISEASE), secondary parkinsonism (see PARKINSON DISEASE, SECONDARY) and inherited forms. These conditions are associated with dysfunction of dopaminergic or closely related motor integration neuronal pathways in the BASAL GANGLIA.

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Proteins associated with sporadic or familial cases of PARKINSON DISEASE.

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