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Helicobacter Pylori Eradication According to DPO-PCR Methods

2019-11-05 16:06:43 | BioPortfolio

Summary

Clarithromycin-containing triple therapy is still the primary therapy approved by the Korean government. However, studies of antibiotic resistance has shown that regional resistance pattern to antibiotics such as clarithromycin is increasing. Recent studies show that examining genotype resistance is effective in eradication. Currently dual priming oligonucleotide-polymerase chain reaction (DPO-PCR) is used to measure clarithromycin resistance. There has been no study of comparing the duration of eradication regimens according to DPO-PCR results. The aim of this study is to compare the eradication rate of 7- day triple therapy with 14-day triple therapy in clarithromycin susceptible strains from DPO-PCR. The investigators also aimed to compare the eradication rates of 7-day bismuth quadruple therapy with 14-day bismuth quadruple therapy from clarithromycin resistant strains from DPO-PCR.

Description

This is a multi-center study perform at three tertiary university hospitals. Patients with H. pylori infection will be treated according to their DPO-PCR results. Patients who are susceptible to clarithromycin will be randomized to receive either triple therapy for 7-days or 14-days. Patients who are resistant to clarithromycin will be randomized to receive either bismuth quadruple therpay for 7-days or 14-days. The eradication rates of each regimens and the adverse events of each regimen will be investigated.

Study Design

Conditions

Helicobacter Pylori Infection

Intervention

Duration of eradication regimen

Location

Incheon St. Mary's Hospital
Incheon
Korea, Republic of

Status

Recruiting

Source

Incheon St.Mary's Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-11-05T16:06:43-0500

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Medical and Biotech [MESH] Definitions

Infections with organisms of the genus HELICOBACTER, particularly, in humans, HELICOBACTER PYLORI. The clinical manifestations are focused in the stomach, usually the gastric mucosa and antrum, and the upper duodenum. This infection plays a major role in the pathogenesis of type B gastritis and peptic ulcer disease.

A spiral bacterium active as a human gastric pathogen. It is a gram-negative, urease-positive, curved or slightly spiral organism initially isolated in 1982 from patients with lesions of gastritis or peptic ulcers in Western Australia. Helicobacter pylori was originally classified in the genus CAMPYLOBACTER, but RNA sequencing, cellular fatty acid profiles, growth patterns, and other taxonomic characteristics indicate that the micro-organism should be included in the genus HELICOBACTER. It has been officially transferred to Helicobacter gen. nov. (see Int J Syst Bacteriol 1989 Oct;39(4):297-405).

A species of gram-negative, spiral-shaped bacteria found in the gastric mucosa that is associated with chronic antral gastritis. This bacterium was first discovered in samples removed at endoscopy from patients investigated for HELICOBACTER PYLORI colonization.

Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

Ulcer that occurs in the regions of the GASTROINTESTINAL TRACT which come into contact with GASTRIC JUICE containing PEPSIN and GASTRIC ACID. It occurs when there are defects in the MUCOSA barrier. The common forms of peptic ulcers are associated with HELICOBACTER PYLORI and the consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).

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