Topics

Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia

2019-11-11 17:49:57 | BioPortfolio

Summary

Neurodegenerative cerebellar ataxias represent a group of disabling disorders which currently lack effective therapies. Cerebellar transcranial direct current stimulation (tDCS) is a non-invasive technique, which has been demonstrated to modulate cerebellar excitability and improve symptoms in patients with cerebellar ataxias. In this randomized, double-blind, sham-controlled study followed by an open-label phase, the investigators will evaluate whether a repetition of two-weeks' treatment with cerebellar anodal tDCS and spinal cathodal tDCS, after a three months interval, may further outlast clinical improvement in patients with neurodegenerative cerebellar ataxia and can modulate cerebello-motor connectivity, at short and long term.

Description

Neurodegenerative cerebellar ataxias represent a heterogeneous group of disabling disorders in which progressive ataxia of gait, limb dysmetria, oculomotor deficits, dysarthria and kinetic tremor are the prominent clinical manifestations. Both the hereditary and sporadic forms usually present in young adulthood, and are characterized by atrophy of cerebellar or brainstem structures. Currently, cerebellar ataxia lack effective disease-modifying therapies.

Cerebellar transcranial direct current stimulation (tDCS) is a non-invasive technique, which has been demonstrated to modulate cerebellar excitability and improve symptoms in patients with cerebellar ataxias. The present randomized, double-blind, sham-controlled study followed by an open-label phase will investigate a repetition of two-weeks' treatment with cerebellar anodal tDCS and spinal cathodal tDCS, after a three months interval, may further outlast clinical improvement in patients with neurodegenerative cerebellar ataxia and can modulate cerebello-motor connectivity, at short and long term. In addition the investigators will evaluate if tDCS intervention might improve cerebellar cognitive-affective syndrome in patients with ataxia.

Study Design

Conditions

Ataxia

Intervention

Anodal cerebellar and cathodal spinal tDCS, Sham cerebellar and sham spinal tDCS

Location

AO Spedali Civili
Brescia
BS
Italy
25100

Status

Recruiting

Source

Azienda Ospedaliera Spedali Civili di Brescia

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-11-11T17:49:57-0500

Clinical Trials [3489 Associated Clinical Trials listed on BioPortfolio]

Rehabilitative Trial With Cerebello-Spinal tDCS in Neurodegenerative Ataxia

Neurodegenerative cerebellar ataxias represent a group of disabling disorders for which we currently lack effective therapies. Cerebellar transcranial direct current stimulation (tDCS) is ...

Optimized tDCS for the Treatment of Migraine

The aim of this study is to establish an optimized protocol of tDCS that normalize the lack of habituation and efficiency of inhibitory cortical circuits in migraine patients and determine...

Effect of ctDCS During Balance Training on Cerebellar Ataxia

Cerebellar ataxia is a neurologic symptom caused by damage or dysfunction in the cerebellum and its pathways that results in loss of coordination, balance and postural control. There is a ...

Rehabilitative Trial With tDCS in Amyotrophic Lateral Sclerosis

Amyotrophic Lateral Sclerosis (ALS) is a motor neuron disease, which is a group of neurological disorders that selectively affect motor neurons, the cells that control voluntary muscles of...

tDCS Associated With Locomotor Training on Functional Mobility of Cerebellar Ataxia

Cerebellar ataxia is a neurologic symptom caused by a damage or a dysfunction in cerebellum and results in loss of coordination, balance and postural control. This impairment could result ...

PubMed Articles [2488 Associated PubMed Articles listed on BioPortfolio]

Polarity- and Intensity-Independent Modulation of Timing During Delay Eyeblink Conditioning Using Cerebellar Transcranial Direct Current Stimulation.

Delay eyeblink conditioning (dEBC) is widely used to assess cerebellar-dependent associative motor learning, including precise timing processes. Transcranial direct current stimulation (tDCS), noninva...

Prefrontal but not cerebellar tDCS attenuates renewal of extinguished conditioned eyeblink responses.

An extended neural network is known to underlie extinction learning. As yet, comparatively little is known about the possible contribution of the cerebellum and the dorsolateral prefrontal cortex (dlP...

Postexercise blood pressure and autonomic responses after aerobic exercise following anodal tDCS applied over the medial prefrontal cortex.

Transcranial direct current stimulation (tDCS) is acknowledged to modulate autonomic cardiac activity and hemodynamic responses at rest and during exercise. However, its potential to optimize postexer...

Anodal occipital tDCS enhances spontaneous alpha activity.

Transcranial direct current stimulation (tDCS) is a form of brain stimulation technique that modulates neuronal excitability changes in targeted cerebral areas through a constant low current. The exis...

Spino-cerebellar tDCS modulates N100 components of the P300 event related potential.

To evaluate the role of the cerebellum and spinal cord in cognitive processes, we assessed changes in event-related potentials (ERPs), before and after different combinations of spinal and cerebellar ...

Medical and Biotech [MESH] Definitions

A condition marked by progressive CEREBELLAR ATAXIA combined with MYOCLONUS usually presenting in the third decade of life or later. Additional clinical features may include generalized and focal SEIZURES, spasticity, and DYSKINESIAS. Autosomal recessive and autosomal dominant patterns of inheritance have been reported. Pathologically, the dentate nucleus and brachium conjunctivum of the CEREBELLUM are atrophic, with variable involvement of the spinal cord, cerebellar cortex, and basal ganglia. (From Joynt, Clinical Neurology, 1991, Ch37, pp60-1)

A subregion of the CEREBELLAR CORTEX, located along the midsagittal plane of the CEREBELLUM.

Primary or metastatic neoplasms of the CEREBELLUM. Tumors in this location frequently present with ATAXIA or signs of INTRACRANIAL HYPERTENSION due to obstruction of the fourth ventricle. Common primary cerebellar tumors include fibrillary ASTROCYTOMA and cerebellar HEMANGIOBLASTOMA. The cerebellum is a relatively common site for tumor metastases from the lung, breast, and other distant organs. (From Okazaki & Scheithauer, Atlas of Neuropathology, 1988, p86 and p141)

Cerebellar degeneration associated with a remote neoplasm. Clinical manifestations include progressive limb and GAIT ATAXIA; DYSARTHRIA; and NYSTAGMUS, PATHOLOGIC. The histologic type of the associated neoplasm is usually carcinoma or lymphoma. Pathologically the cerebellar cortex and subcortical nuclei demonstrate diffuse degenerative changes. Anti-Purkinje cell antibodies (anti-Yo) are found in the serum of approximately 50% of affected individuals. (Adams et al., Principles of Neurology, 6th ed, p686)

Diseases that affect the structure or function of the cerebellum. Cardinal manifestations of cerebellar dysfunction include dysmetria, GAIT ATAXIA, and MUSCLE HYPOTONIA.

More From BioPortfolio on "Cerebello-Spinal tDCS as Rehabilitative Intervention in Neurodegenerative Ataxia"

Quick Search

Searches Linking to this Trial