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A Study of the Safety and Activity of Eculizumab in Pediatric Participants With Relapsing Neuromyelitis Optica Spectrum Disorder

2019-11-12 18:25:31 | BioPortfolio

Summary

The objective of this study is to evaluate the safety and efficacy of eculizumab in pediatric participants (aged 2 to < 18 years) with relapsing neuromyelitis optica spectrum disorder (NMOSD).

Study Design

Conditions

Neuromyelitis Optica

Intervention

Eculizumab

Location

University of California San Francisco
San Francisco
California
United States
94143

Status

Not yet recruiting

Source

Alexion Pharmaceuticals

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-11-12T18:25:31-0500

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PubMed Articles [101 Associated PubMed Articles listed on BioPortfolio]

Eculizumab in Aquaporin-4-Positive Neuromyelitis Optica Spectrum Disorder.

Neuromyelitis optica spectrum disorder (NMOSD) is a relapsing, autoimmune, inflammatory disorder that typically affects the optic nerves and spinal cord. At least two thirds of cases are associated wi...

The latest diagnostic criteria and treatment options for neuromyelitis optica.

Neuromyelitis optica, also known as Devic disease, is an autoimmune disorder that affects the spinal cord and optic nerve. This atypical demyelinating syndrome can be difficult to diagnose and respond...

GRP 78 antibodies are associated with clinical phenotype in neuromyelitis optica.

We previously reported the association between blood-brain barrier (BBB) dysfunction and glucose-regulated protein 78 (GRP 78) autoantibodies in neuromyelitis optica (NMO).

HLA-alleles class I and II associated with genetic susceptibility to neuromyelitis optica in Brazilian patients.

To study the genetic susceptibility to neuromyelitis optica (NMO) as well as the relationship between HLA genotypes and susceptibility to the disease in the southern Brazilian population.

General anaesthesia for caesarean section in a patient with neuromyelitis optica spectrum disorder (NMOSD).

Neuromyelitis optica spectrum disorder (NMOSD) is a rare demyelinating disorder affecting the spinal cord and optic nerves. The anesthetic management in parturient women with NMOSD are controversial a...

Medical and Biotech [MESH] Definitions

A syndrome characterized by acute OPTIC NEURITIS in combination with acute MYELITIS, TRANSVERSE. Demyelinating and/or necrotizing lesions form in one or both optic nerves and in the spinal cord. The onset of optic neuritis and myelitis may be simultaneous or separated by several months. (J Neurol Neurosurg Psychiatry 1996 Apr;60(4):382-387)

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