Mediterranean Diet Versus Exercise to Lower Cardiometabolic Risk

2019-11-12 18:25:33 | BioPortfolio


Rates of overweight and obesity continue to climb globally, also in Norway. Cardiometabolic consequences of body fat accumulation includes diabetes type 2 and cardiovascular disease. Progress is needed towards ameliorating these risk, particulary in vulnerable patients. Modifying energy balance has proven to be difficult. Adiposity is activly regulated and defended in obese as in normal weight persons.Thus, most weight loss attempts are followed by weight regain. Lifestyle improvements give substantial benefits and may be preferable to unsuccessful and repeated attempts to loose weight permanently


Patient with obesity and ectopic fat (examples: visceral, pancreatic, intramuscular, hepatic) and risk og type 2 diabetes and cardiovascular disease (CVD) benefit from interventions that lower body weight. Diet and physical activity are optimal. Adherence to a Mediterranean diet with and without weight loss reduce the incidence of CVD and was superiour to a low fat diet in lowering ectopic fat. Exercise lowers risk of type 2 diabetes and contributes to weight loss. Addition of exercise after 6 month of dieting decreased visceral fat without weight loss, suggesting that reduction in ectopic fat in addition to increased lean body mass explain the benefits of exercise.

Poor motivation, physical limitations, socioeconomic factors and lack of enjoyment of exercise are common. and represent a major barrier to lifestyle change. Initiating one lifestyle change at a time (diet or exercise) may improve adherence.

Studies examining the effects og lifestyle change on disease outcomes are difficult to conduct due to long follow up and large samples required. In the abscence of of hard outcomes, surrogate endpoints are of considerable importance in guiding lifestyle advice. Recently software has been developed to quantify ectopic fat deposits using MRI technology.

To our knowledge, studies looking at the differential effects of dietary change versus physical activity on ectopic fat deposits using advanced technology have not been done.

Study Design


Overweight or Obesity


energy deficit


Oslo University Hospital, Aker


Not yet recruiting


Oslo University Hospital

Results (where available)

View Results


Published on BioPortfolio: 2019-11-12T18:25:33-0500

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