Exercise in Adolescents With Insulin Resistance

2019-11-12 18:25:34 | BioPortfolio


The growing population of adolescents with insulin resistance (IR) is predicted to create a large public health burden in the next few decades. This study examines the function of brain blood vessels and cognitive function, to test if increasing severity of IR in adolescents is related to reduced cognitive function and reduced brain blood vessel function. Findings from this study may help create treatments to delay or prevent some of the negative effects of IR on cognitive and vascular health.


One in five American adolescents are obese, and many of these patients exhibit some level of insulin resistance (IR). IR is associated with cerebrovascular disease, reduced memory, attention, and cognition, but how IR contributes to these in the course of adolescent brain development is unclear. The goal of this proposal is to investigate the extent and by which IR drives reductions in neurocognitive function and cerebral blood flow (CBF) in adolescents at elevated risk for poor brain and cerebrovascular health. The overall goal of this research program is to investigate IR-related changes in neurocognitive and vascular function. The investigators propose to study adolescents across a spectrum of IR, from healthy to pre-diabetic, without confounding effects of age or diabetes— before the negative effects of IR can exert their full negative impact. The general hypothesis is that cognitive and vascular function is impaired due to dysfunctional brain blood vessel responses.

Study Design


Insulin Resistance


Hypercapnia, Transcranial Doppler, Cycle ergometer, Cognitive Tests


University of Wisconsin-Madison
United States




University of Wisconsin, Madison

Results (where available)

View Results


Published on BioPortfolio: 2019-11-12T18:25:34-0500

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A non-invasive technique using ultrasound for the measurement of cerebrovascular hemodynamics, particularly cerebral blood flow velocity and cerebral collateral flow. With a high-intensity, low-frequency pulse probe, the intracranial arteries may be studied transtemporally, transorbitally, or from below the foramen magnum.

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