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The Drug-Drug Interaction of SHR4640 and Febuxostat in Patients With Hyperuricemia

2019-11-14 17:39:49 | BioPortfolio

Summary

The objective of the study is to assess the pharmacodynamic properties of drug-drug of SHR4640 and Febuxostat interaction in patients with Hyperuricemia.

Study Design

Conditions

Hyperuricemia

Intervention

SHR4640 dose1, Febuxostat dose2

Location

The Affiliated Hospital of QingDao University
Qingdao
Shan Dong
China

Status

Recruiting

Source

Jiangsu HengRui Medicine Co., Ltd.

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-11-14T17:39:49-0500

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A Study of Evaluating the Efficacy and Safety of SHR4640 in Subjects With Gout

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Febuxostat-Controlled, Double-Blind, Comparative Study of FYU-981 in Hyperuricemia With or Without Gout

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Study of Tranilast Alone or in Combination With Febuxostat in Patients With Hyperuricemia

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PubMed Articles [56 Associated PubMed Articles listed on BioPortfolio]

Comparison of long-term efficacy and renal safety of febuxostat and allopurinol in patients with chronic kidney diseases
.

Febuxostat, a novel non-purine selective xanthine oxidase inhibitor, is a recommended treatment option for patients with chronic kidney disease (CKD) and hyperuricemia. There are only a few trials on ...

Effects of febuxostat on renal function in patients with chronic kidney disease: A systematic review and meta-analysis.

Hyperuricemia has been proven to be an independent risk factor for chronic kidney disease (CKD). However, the role of hyperuricemia in the progression of CKD remains unclear. Thus, we performed a syst...

Comparative Renoprotective Effect of Febuxostat and Allopurinol in Pre-Dialysis Stage 5 Chronic Kidney Disease Patients: A Nationwide Database Analysis.

Hyperuricemia has been associated with chronic kidney disease (CKD) progression. The anti-hyperuricemic febuxostat's potential renoprotective effect has been demonstrated in stage 1-3 CKD. Large-scale...

Hyperuricemia is associated with impaired intestinal permeability in mice.

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Diagnosis and treatment for hyperuricemia and gout: a systematic review of clinical practice guidelines and consensus statements.

Despite the publication of hundreds of trials on gout and hyperuricemia, management of these conditions remains suboptimal. We aimed to assess the quality and consistency of guidance documents for gou...

Medical and Biotech [MESH] Definitions

A thiazole derivative and inhibitor of XANTHINE OXIDASE that is used for the treatment of HYPERURICEMIA in patients with chronic GOUT.

Excessive URIC ACID or urate in blood as defined by its solubility in plasma at 37 degrees C; greater than 0.42mmol per liter (7.0mg/dL) in men or 0.36mmol per liter (6.0mg/dL) in women. This condition is caused by overproduction of uric acid or impaired renal clearance. Hyperuricemia can be acquired, drug-induced or genetically determined (LESCH-NYHAN SYNDROME). It is associated with HYPERTENSION and GOUT.

Hereditary metabolic disorder characterized by recurrent acute arthritis, hyperuricemia and deposition of sodium urate in and around the joints, sometimes with formation of uric acid calculi.

A syndrome resulting from cytotoxic therapy, occurring generally in aggressive, rapidly proliferating lymphoproliferative disorders. It is characterized by combinations of hyperuricemia, lactic acidosis, hyperkalemia, hyperphosphatemia and hypocalcemia.

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