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This study will be conducted in subjects with established Parkinson's disease in 2 parts. Part A will examine the tolerability, safety, and pharmacokinetics of AZ-009 dose escalation ; and Part B will assess the tolerability, safety, pharmacokinetics, and pharmacodynamics of AZ-009 compared with placebo in a crossover design
This study will be conducted in subjects with established Parkinson's disease in 2 parts.
Part A will examine the tolerability, safety, and pharmacokinetics of daily doses of AZ-009 for 5 days followed by 3 doses on each of days 6 and 7 in dose escalation through 3 cohorts
Part B will assess the tolerability, safety, pharmacokinetics, and pharmacodynamics of AZ-009 compared with placebo in subjects with established Parkinson's disease experiencing regular OFF episodes
009-A1, 009-A2, 009-A3, 009-A0, 009-B1 (active --> placebo) crossover, 009-B2 (placebo --> active) crossover
Centre for Human Drug Research
Enrolling by invitation
Alexza Pharmaceuticals, Inc.
Published on BioPortfolio: 2019-11-12T18:25:13-0500
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