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A Study to Test the Effect of Empagliflozin in Patients Who Are in Hospital for Acute Heart Failure

2019-11-11 17:49:16 | BioPortfolio

Summary

To assess whether in-hospital administration of empagliflozin results n improvements in HF related clinical events and patient-reported outcomes (death, HFE and KCCQ-CSS as a measure of health status (symptoms and physical limitations)) in patients hospitalised for acute heart failure (de novo or decompensated chronic HF) and after initial stabilisation.

Study Design

Conditions

Heart Failure

Intervention

Empagliflozin, Placebo to Empagliflozin

Status

Not yet recruiting

Source

Boehringer Ingelheim

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-11-11T17:49:16-0500

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PubMed Articles [7431 Associated PubMed Articles listed on BioPortfolio]

Therapy of empagliflozin plus metformin on T2DM mice shows no higher amelioration for glucose and lipid metabolism than empagliflozin monotherapy.

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Medical and Biotech [MESH] Definitions

A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying.

Heart failure caused by abnormal myocardial relaxation during DIASTOLE leading to defective cardiac filling.

Agents that have a strengthening effect on the heart or that can increase cardiac output. They may be CARDIAC GLYCOSIDES; SYMPATHOMIMETICS; or other drugs. They are used after MYOCARDIAL INFARCT; CARDIAC SURGICAL PROCEDURES; in SHOCK; or in congestive heart failure (HEART FAILURE).

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