Effect of Short-term Oxygen During CPET in HFpEF

2019-11-14 17:39:51 | BioPortfolio


In a randomized, sham-controlled crossover trial the investigators will test whether supplemental oxygen given during cardiopulmonary exercise testing will improve exercise performance and physiological parameters in patients with heart failure with preserved ejection fraction.

Study Design


Heart Failure, Diastolic (HFpEF)


Oxygen application, Sham room air


University Hospital Zurich, Division of Pneumology




University of Zurich

Results (where available)

View Results


Published on BioPortfolio: 2019-11-14T17:39:51-0500

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Medical and Biotech [MESH] Definitions

Heart failure caused by abnormal myocardial relaxation during DIASTOLE leading to defective cardiac filling.

A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

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Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

Heart sounds caused by vibrations resulting from the flow of blood through the heart. Heart murmurs can be examined by HEART AUSCULTATION, and analyzed by their intensity (6 grades), duration, timing (systolic, diastolic, or continuous), location, transmission, and quality (musical, vibratory, blowing, etc).

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