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Hemadsorption During and After Cardiopulmonary Bypass to Modulate the Inflammatory Response

2019-11-14 17:39:51 | BioPortfolio

Summary

Chronic kidney disease (CKD) is a risk factor for the development of cardiovascular disease, which increases the risk of death after cardiac surgery. High interleukin 6 (IL-6) blood levels is commonly observed in patients with CKD, and this is particularly high after cardiac surgery. High IL-6 levels are also associated with increased long-term mortality rate after cardiac surgery. To date, the use of ultrafiltration or endotoxin adsorption systems were not found to improve the clinical outcome, although able to reduce the inflammatory mediators concentrations. In the last years, a new extracorporeal hemadsorption filter (CytoSorb) has been developed for removal of inflammatory cytokines and it has been approved by the European Union. However, data lack about the impact on clinical outcome of the use of CytoSorb in patients with CKD undergoing cardiac surgery with cardio-pulmonary bypass (CPB). The investigators have therefore designed this pilot prospective randomized trial to evaluate the efficacy the intraoperative use of CytoSorb for cytokines removal to prevent the inflammatory response associated with the cardiac surgery and complications in patients with CKD.

Study Design

Conditions

Inflammatory Response

Intervention

CytoSorb, Control

Location

AOU Mater Domini
Catanzaro
CZ
Italy
88100

Status

Not yet recruiting

Source

University Magna Graecia

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-11-14T17:39:51-0500

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