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Co-infusion of Neurotensin and GLP-1 Effects on Appetite and Food Intake.

2019-12-08 01:41:37 | BioPortfolio

Summary

Co-infusion of Neurotensin and GLP-1 Effects on Appetite and Food Intake.

Description

Neurotensin (NT), a gut hormone and neuropeptide, and GLP-1, as well a gut hormone, increases in circulation after bariatric surgery in rodents and humans and inhibit food intake in mice.

Studies in rodents have shown that a GLP-1 receptor agonist and long acting neurotensin inhibit food intake.

This study investigates whether the synergistic anorexic effects of neurotensin and GLP-1 agonism suggested by animal studies can be translated.

Study Design

Conditions

Obesity

Intervention

Saline + saline, Neurotensin + saline, GLP-1 + saline, GLP-1 + Neurotensin

Location

University of Copenhagen, Department of Biomedical Scienses
Copenhagen
Denmark
2200

Status

Recruiting

Source

University of Copenhagen

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-12-08T01:41:37-0500

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Medical and Biotech [MESH] Definitions

A genus of HALOBACTERIACEAE distinguished from other genera in the family by the presence of specific derivatives of TGD-2 polar lipids. Haloarcula are found in neutral saline environments such as salt lakes, marine salterns, and saline soils.

A family of gram-negative, moderately halophilic bacteria in the order Oceanospirillales. Members of the family have been isolated from temperate and Antarctic saline lakes, solar salt facilities, saline soils, and marine environments.

Cell surface proteins that bind neurotensin with high affinity and trigger intracellular changes which influence the behavior of cells. Neurotensin and neurotensin receptors are found in the central nervous system and in the periphery.

A species of PERCIFORMES commonly used in saline aquaculture.

Water from natural sources which contain significant concentrations of dissolved salts such as sodium chloride.

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