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Clinical Study New Gel for Xerostomia

2019-12-09 00:56:24 | BioPortfolio

Summary

At present, there is no single consensus protocol for the treatment of oral dryness, although the main objective is to improve the quality of life of patients. Current therapy for the control of xerostomia is based on the following measures:

1. General measures ; review and control of drugs,hydration and dietary advice:

The main recommendations are found in the following scheme.

2. Saliva stimulants( Topics and sistemic )The option of using chewing stimuli by chewing gum with non-cariogenic sweeteners helps to improve symptoms. The investigators can also use gustatory stimuli, such as citric acid that is a potent stimulator of salivary secretion.

Among the most commonly used pharmacological agents are: pilocarpine, bethanecol, civemiline

3. Saliva substitutes or artificial saliva. Saliva substitutes can provide a moisture retention layer in the oral mucosa and can be administered by liquids, spray, pills or gels. Topical treatments have few adverse effects and improve the quality of life of patients with xerostomia; In addition, they maintain oral health.

Description

Randomized, double-blind, placebo-controlled clinical study to evaluate the efficacy and tolerability in patients with a non-commercialized gel and property of the promoter to treat xerostomia.

Study Design

Conditions

XEROSTOMIA

Intervention

gel xerostomia, gel placebo

Location

Lopez-Jornet Pia
Murcia
N/A = Not Applicable
Spain
30008

Status

Recruiting

Source

Universidad de Murcia

Results (where available)

View Results

Links

Published on BioPortfolio: 2019-12-09T00:56:24-0500

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Medical and Biotech [MESH] Definitions

Decreased salivary flow.

A solution used for irrigating the mouth in xerostomia and as a substitute for saliva.

Drying and inflammation of the conjunctiva as a result of insufficient lacrimal secretion. When found in association with XEROSTOMIA and polyarthritis, it is called SJOGREN'S SYNDROME.

Chronic inflammatory and autoimmune disease in which the salivary and lacrimal glands undergo progressive destruction by lymphocytes and plasma cells resulting in decreased production of saliva and tears. The primary form, often called sicca syndrome, involves both KERATOCONJUNCTIVITIS SICCA and XEROSTOMIA. The secondary form includes, in addition, the presence of a connective tissue disease, usually rheumatoid arthritis.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

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