Computational Modeling of 60 Hz Subthalamic Nucleus Deep Brain Stimulation for Gait Disorder in Parkinson's Disease

2019-12-09 00:56:25 | BioPortfolio


The objective of this study is to further the understanding and application of 60Hz subthalamic deep brain stimulation (STN-DBS) in Parkinson's patients with gait disorder. The investigators will achieve this through 2 study aims:

1. Determine the impact of 60Hz subthalamic deep brain stimulation on gait kinematics using wearable sensors

2. Develop machine learning models to predict optimal subthalamic deep brain stimulation frequency based on wearable sensors


Gait disorder, which manifests as shuffling, reduction in speed, multistep turning, and/or freezing of gait (FOG), can arise later in the Parkinson's disease (PD) course and cause significant disability. Ultimately, patients are at risk for falls and can become socially isolated due to their mobility limitations. These symptoms tend not to respond to high frequency STN-DBS. However, lower frequency stimulation (60-80Hz) of the STN in treating gait disorder and/or freezing of gait has demonstrated benefit. This study potentially can expand knowledge of 60hz DBS while improving its utilization in combination with PD medications—enabling sustainable and possibly predictable therapeutic benefit.

Study Design


Parkinson Disease


Deep Brain Stimulation


Northwell Health
Great Neck
New York
United States




Northwell Health

Results (where available)

View Results


Published on BioPortfolio: 2019-12-09T00:56:25-0500

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