Stopping Maintenance Therapy in People With Multiple Myeloma in MRD-Negative Remission

2020-01-14 10:02:54 | BioPortfolio


This study will test whether stopping maintenance therapy in people with multiple myeloma in MRD-negative remission has the same effect on disease control as continuing this therapy. The study will look at whether people currently on maintenance therapy can safely stop this treatment and continue with active surveillance instead while keeping their MRD-negative remission status for at least 1 year.

Study Design


Plasma Cell Myeloma


Cessation of continuous matinenace therapy


Memorial Sloan Kettering Cancer Center
New York
New York
United States




Memorial Sloan Kettering Cancer Center

Results (where available)

View Results


Published on BioPortfolio: 2020-01-14T10:02:54-0500

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Medical and Biotech [MESH] Definitions

An asymptomatic and slow-growing PLASMA CELL dyscrasia characterized by presence of MYELOMA PROTEINS and clonal bone marrow plasma cells without end-organ damage (e.g., renal impairment). It is distinguished from MONOCLONAL GAMMOPATHY OF UNDETERMINED SIGNIFICANCE by a much higher risk of progression to symptomatic MULTIPLE MYELOMA.

A rare, aggressive variant of MULTIPLE MYELOMA characterized by the circulation of excessive PLASMA CELLS in the peripheral blood. It can be a primary manifestation of multiple myeloma or develop as a terminal complication during the disease.

Abnormal immunoglobulins characteristic of MULTIPLE MYELOMA.

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