Genotypic Influences on Network Progression in Parkinson's Disease

2020-01-21 11:32:37 | BioPortfolio


In this longitudinal study, the investigators will follow Parkinson's disease (PD) patients with and without glucocerebrosidase (GBA) mutations. The investigators hypothesize that the rate of increase in brain network activity over time (network progression rate) is faster in patients with GBA gene mutations.


Parkinson's disease (PD) patients with mutations in the glucocerebrosidase gene (GBA) tend to have a more aggressive disease course. GBA may therefore provide a target for disease modifying therapies in mutation carriers. Using positron emission tomography (PET) and magnetic resonance imaging (MRI) brain imaging to measure network progression rates in mutation carriers will allow for the assessment of the potential disease modifying effects of new anti-GBA therapies.

The investigators will also determine whether magnetic resonance imaging (MRI) network methods, which are less invasive and more broadly available than positron emission tomography (PET), produce comparable network progression measurements in individual patients. These determinations will be critical for the design of clinical trials of new disease-modifying drugs.

Study Design


Parkinson's Disease


DNA/GeneticTesting, FDG PET scan, MRI scan, Clinical and neuropsychological assessments


Feinstein Institutes for Medical Research
New York
United States




Northwell Health

Results (where available)

View Results


Published on BioPortfolio: 2020-01-21T11:32:37-0500

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