Establishment of a Cohort of Patients With Sepsis Encephalopathy

2020-01-19 11:04:30 | BioPortfolio


In this study, the investigators aimed to initially explore and describe the expression profiles, pathological processes, and molecular mechanisms of cytokine differential indicators such as NLRP3, NLRP1, and AIM2 in patients with SAE by establishing a cohort of SAE patients; and anchoring by enrichment analysis Risk cytokines and pathways related to the occurrence of SAE patients; provide theoretical guidance and basis for in-depth study of SAE occurrence mechanism and screening of early warning indicators and treatment targets.


According to the inclusion and exclusion criteria of this study, relevant patients who attended the emergency department of our hospital were collected, and the SAE cohort was established. participants were divided into SAE group and non-SAE group based on whether SAE occurred after discharge and one year follow-up. Another 20 patients with non-infected SIRS were selected as the control group.For the above three groups of patients, at the same time as the biochemical, routine, and culture examinations of lumbar puncture and cerebrospinal fluid, 5 ml of cerebrospinal fluid was retained for cytokine detection such as NLRP1, NLRP3, AIM2, and NURRI.All were given active anti-shock, and actively sought for infections through traditional imaging and quantum dot spectroscopy techniques for targeted anti-infective therapy, maintenance of circulation and stable internal environment.Research main indicators:Patient baseline data, GCS, CAM-ICU, RASS, APACHE-II, SOFA, IL, IL6, CPR, PCT, WBC, N%, liver and kidney function indicators, NLRP1, NLRP3, AIM2 and other indicators, follow-up of patient survival rate.

Study Design


Sepsis Encephalopathy


No intervention


Not yet recruiting


Peking Union Medical College Hospital

Results (where available)

View Results


Published on BioPortfolio: 2020-01-19T11:04:30-0500

Clinical Trials [717 Associated Clinical Trials listed on BioPortfolio]

Pathogenesis and Cerebrovascular Manifestations of Septic Encephalopathy

Septic encephalopathy is an important complication of sepsis. Why some patients with sepsis develop septic encephalopathy is unknown. We will investigate whether patients who develop this ...

Adjunctive Sedation With Dexmedetomidine for the Prevention of Severe Inflammation and Septic Encephalopathy

Septic encephalopathy (SE) is defined as acute cerebral dysfunction in patients with sepsis or septic shock. SE occurs in up to 50% of critically ill patients with sepsis and is associated...

Bispectral Index (BIS) for Classification of Procalcitonin (PCT) Sepsis Grades in Critically Ill Patients With Sepsis

To evaluate the discriminative power of BIS monitoring to classify the degree of mental state associated with the PCT graded sepsis cascade, and to assess its utility for monitoring the im...

Predictive algoRithm for EValuation and Intervention in SEpsis

In this prospective study, the ability of a machine learning algorithm to predict sepsis and influence clinical outcomes, will be investigated at Cabell Huntington Hospital (CHH).

Acute Phase Proteins as Early Markers in Sepsis

Monitoring of different serumproteins after severe trauma and during trauma-induced sepsis. - Trial with surgical intervention

PubMed Articles [4769 Associated PubMed Articles listed on BioPortfolio]

Long-term courses of sepsis survivors: effects of a primary care management intervention.

Sepsis survivors face mental and physical sequelae even years after discharge from the intensive care unit (ICU). The aim of this study was to evaluate the long-term courses of sepsis survivors and th...

Borneol alleviates brain injury in sepsis mice by blocking neuronal effect of endotoxin.

Brain injury after sepsis leads to high mortality and long-term brain dysfunction in patients. Previous studies revealed that borneol has a protective effect on the brain, but its function on sepsis a...

Plasma miR-370-3p As a Biomarker of Sepsis-Associated Encephalopathy, The Transcriptomic Profiling Analysis of Microrna-Arrays From Mouse Brains.

The diagnosis of sepsis-associated encephalopathy (SAE), an alteration of conscious from sepsis, is difficult due to the similarity to altered states of conscious that occur from other causes. Transcr...

Improving Sepsis Bundle Implementation Times: A Nursing Process Improvement Approach.

Early recognition of sepsis in the emergency room (ER) has been shown to improve treatment intervention times and decrease mortality.

Progress in programmed death-1 signaling pathway in sepsis.

Sepsis includes a highly diverse and dynamic mixture of systemic inflammatory response syndrome (SIRS) and compensatory anti-inflammatory response syndrome (CARS). In the past, drugs produced to block...

Medical and Biotech [MESH] Definitions

Acute neurological dysfunction during severe SEPSIS in the absence of direct brain infection characterized by systemic inflammation and BLOOD BRAIN BARRIER perturbation.

Systemic inflammatory response syndrome with a proven or suspected infectious etiology. When sepsis is associated with organ dysfunction distant from the site of infection, it is called severe sepsis. When sepsis is accompanied by HYPOTENSION despite adequate fluid infusion, it is called SEPTIC SHOCK.

Blood infection that occurs in an infant younger than 90 days old. Early-onset sepsis is seen in the first week of life and most often appears within 24 hours of birth. Late-onset occurs after 1 week and before 3 months of age.

A study in which observations are made before and after an intervention, both in a group that receives the intervention and in a control group that does not.

A study that uses observations at multiple time points before and after an intervention (the "interruption"), in an attempt to detect whether the intervention has had an effect significantly greater than any underlying trend over time.

More From BioPortfolio on "Establishment of a Cohort of Patients With Sepsis Encephalopathy"

Quick Search

Relevant Topics

Cytokine Tumour Necrosis Factor (TNF)
TNF is a compound that is classified as a cytokine which plays a central role in the cellular mechanisms of apoptosis or cell death. However, there are a number of different kinds of TNF, just under twenty, but the family of molecules have very similar a...

Biological Therapy
Biological therapy involves the use of living organisms, substances derived from living organisms, or laboratory-produced versions of such substances to treat disease. Some biological therapies for cancer use vaccines or bacteria to stimulate the body&rs...

Searches Linking to this Trial