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In this study, the investigators aimed to initially explore and describe the expression profiles, pathological processes, and molecular mechanisms of cytokine differential indicators such as NLRP3, NLRP1, and AIM2 in patients with SAE by establishing a cohort of SAE patients; and anchoring by enrichment analysis Risk cytokines and pathways related to the occurrence of SAE patients; provide theoretical guidance and basis for in-depth study of SAE occurrence mechanism and screening of early warning indicators and treatment targets.
According to the inclusion and exclusion criteria of this study, relevant patients who attended the emergency department of our hospital were collected, and the SAE cohort was established. participants were divided into SAE group and non-SAE group based on whether SAE occurred after discharge and one year follow-up. Another 20 patients with non-infected SIRS were selected as the control group.For the above three groups of patients, at the same time as the biochemical, routine, and culture examinations of lumbar puncture and cerebrospinal fluid, 5 ml of cerebrospinal fluid was retained for cytokine detection such as NLRP1, NLRP3, AIM2, and NURRI.All were given active anti-shock, and actively sought for infections through traditional imaging and quantum dot spectroscopy techniques for targeted anti-infective therapy, maintenance of circulation and stable internal environment.Research main indicators:Patient baseline data, GCS, CAM-ICU, RASS, APACHE-II, SOFA, IL, IL6, CPR, PCT, WBC, N%, liver and kidney function indicators, NLRP1, NLRP3, AIM2 and other indicators, follow-up of patient survival rate.
Not yet recruiting
Peking Union Medical College Hospital
Published on BioPortfolio: 2020-01-19T11:04:30-0500
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A study in which observations are made before and after an intervention, both in a group that receives the intervention and in a control group that does not.
A study that uses observations at multiple time points before and after an intervention (the "interruption"), in an attempt to detect whether the intervention has had an effect significantly greater than any underlying trend over time.
Cytokine Tumour Necrosis Factor (TNF)
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