Topics

UCPVax Plus Nivolumab Versus Docetaxel as Second Line Therapy in Advanced Non Small Cell Lung Cancer

2020-02-16 17:41:18 | BioPortfolio

Summary

Lung cancer is the most commonly diagnosed malignancy and the leading cause of cancer-related mortality both in men and women worldwide. NSCLC accounts for about 85% of lung cancers. Median survival for patients with advanced NSCLC ranges between 8 and 10 months for those with squamous tumors to 10 to 14 months for molecularly unselected patients with adenocarcinoma enrolled in the most recent phase III clinical trials of modern chemotherapy regimens. Thus, there is a clear need to improve the therapeutic options for the treatment of patients with NSCLC disease.

Immunotherapy is proven to be an effective therapeutic approach in a variety of cancers and is likely to become a key part of the clinical management of NSCLC. The basic concept of these anticancer ICB therapies is to restore antitumor immunity, especially T cell functions.

Nivolumab (NIVO), which is an anti-PD-1 antibody, has shown promising results in 2nd line treatment for advanced NSCLC.

UCPVAx is a therapeutic vaccine based on the telomerase-derived UCP designed to induce strong TH1 CD4 T cell responses in cancer patients.

So investigators propose to evaluate the efficacy of UCPVax plus Nivolumab in patients with advanced non small cell lung cancer as second line systemic therapy.

Study Design

Conditions

Stage IV Non-small Cell Lung Cancer

Intervention

CT scan, Blood sample collection, Fecal sample collection

Location

CHU of Besançon
Besançon
France
250000

Status

Not yet recruiting

Source

Centre Hospitalier Universitaire de Besancon

Results (where available)

View Results

Links

Published on BioPortfolio: 2020-02-16T17:41:18-0500

Clinical Trials [6833 Associated Clinical Trials listed on BioPortfolio]

Blood Sample Collection in Subjects With Pulmonary Nodules or CT Suspicion of Lung Cancer or Pathologically Diagnosed Lung Cancer

The primary objective of this study is to obtain de-identified, clinically characterized, whole blood specimens for use in assessing new biomarkers for the detection of neoplasms of the lu...

Optimization of Collection Methods for Studies of the Human Microbiota

Background: The human microbiome is the microbial genes found in and on the human body. Scientists study the microbiome because it is related to many health conditions. The way samples ar...

Blood Sample Collection to Evaluate Biomarkers for Hepatocellular Carcinoma

The primary objective of this study is to obtain de-identified, clinically-characterized whole blood specimens for use in developing and evaluating the performance of new biomarker assays ...

Study Looking at Biomarkers in Ovarian Cancer

This is a sample study that will collect biological samples (blood, tumor tissue, ascites, and/or other fluids) from gynecological cancer patients for biomarker research. In addition, the ...

Febrile Whole Blood Specimen Collection and Testing

Whole blood samples will be collected from febrile patients presenting with fever of unknown origin and flu-like syndromes. Collection sites will consent patients and collect one (1) 4 mL ...

PubMed Articles [17232 Associated PubMed Articles listed on BioPortfolio]

Evaluating rectal swab collection method for gut microbiome analysis in the common marmoset (Callithrix jacchus).

The common marmoset (Callithrix jacchus) is increasingly used as an animal model for biomedical research; however, gastrointestinal diseases causing significant morbidity are endemic in many captive m...

Reproducibility, stability, and accuracy of microbial profiles by fecal sample collection method in three distinct populations.

The gut microbiome likely plays a role in the etiology of multiple health conditions, especially those affecting the gastrointestinal tract. Little consensus exists as to the best, standard methods to...

Development of an integrated fingerstick blood self-collection device for radiation countermeasures.

We report the development of system for packaging critical components of the traditional collection kit to make an integrated fingerstick blood collector for self-collecting blood samples of 100 μl o...

Effects of stylet-in versus stylet-out collection of cerebrospinal fluid from the cisterna magna on contamination of samples, sample quality, and collection time.

To evaluate safety of stylet-in and stylet-out techniques for collection of CSF from the cisterna magna and to assess whether there were differences between techniques with regard to contamination of ...

Utilization of Mobile Application for Better Implementation of Good Clinical Practice in a Biorepository Sample Collection Process: Functions of in Biobanking.

Preanalytical variables of biospecimens play a vital role in biobanking. Currently, there is a lack of a convenient and precise methods to document these variables. Paper documentation and computer-ba...

Medical and Biotech [MESH] Definitions

The taking of a blood sample to determine its character as a whole, to identify levels of its component cells, chemicals, gases, or other constituents, to perform pathological examination, etc.

Development of a library collection, including the determination and coordination of selection policy, assessment of needs of users and potential users, collection use studies, collection evaluation, identification of collection needs, selection of materials, planning for resource sharing, collection maintenance and weeding, and budgeting.

Laboratory processes prior to specimen analysis. These processes include study design, compliance of the subjects investigated, compliance in adherence to protocols, choice of specimens utilized and sample collection.

The analysis of a chemical substance by inserting a sample into a carrier stream of reagent using a sample injection valve that propels the sample downstream where mixing occurs in a coiled tube, then passes into a flow-through detector and a recorder or other data handling device.

A type of scanning probe microscopy in which a very sharp conducting needle is swept just a few angstroms above the surface of a sample. The tiny tunneling current that flows between the sample and the needle tip is measured, and from this are produced three-dimensional topographs. Due to the poor electron conductivity of most biological samples, thin metal coatings are deposited on the sample.

More From BioPortfolio on "UCPVax Plus Nivolumab Versus Docetaxel as Second Line Therapy in Advanced Non Small Cell Lung Cancer"

Quick Search

Relevant Topics

Cancer
  Bladder Cancer Brain Cancer Breast Cancer Cancer Cervical Cancer Colorectal Head & Neck Cancers Hodgkin Lymphoma Leukemia Lung Cancer Melanoma Myeloma Ovarian Cancer Pancreatic Cancer ...

Cancer Disease
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...

Women's Health
Women's Health - key topics include breast cancer, pregnancy, menopause, stroke Follow and track Women's Health News on BioPortfolio: Women's Health News RSS Women'...


Searches Linking to this Trial