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Lung cancer is the most commonly diagnosed malignancy and the leading cause of cancer-related mortality both in men and women worldwide. NSCLC accounts for about 85% of lung cancers. Median survival for patients with advanced NSCLC ranges between 8 and 10 months for those with squamous tumors to 10 to 14 months for molecularly unselected patients with adenocarcinoma enrolled in the most recent phase III clinical trials of modern chemotherapy regimens. Thus, there is a clear need to improve the therapeutic options for the treatment of patients with NSCLC disease.
Immunotherapy is proven to be an effective therapeutic approach in a variety of cancers and is likely to become a key part of the clinical management of NSCLC. The basic concept of these anticancer ICB therapies is to restore antitumor immunity, especially T cell functions.
Nivolumab (NIVO), which is an anti-PD-1 antibody, has shown promising results in 2nd line treatment for advanced NSCLC.
UCPVAx is a therapeutic vaccine based on the telomerase-derived UCP designed to induce strong TH1 CD4 T cell responses in cancer patients.
So investigators propose to evaluate the efficacy of UCPVax plus Nivolumab in patients with advanced non small cell lung cancer as second line systemic therapy.
Stage IV Non-small Cell Lung Cancer
CT scan, Blood sample collection, Fecal sample collection
CHU of Besançon
Not yet recruiting
Centre Hospitalier Universitaire de Besancon
Published on BioPortfolio: 2020-02-16T17:41:18-0500
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