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A Study of Pharmacodynamic and Genetic Parameters of Abira-DES Study Participants (NCT02217566) - Participants With Metastatic Castration-Resistant Prostate Cancer Treated With Abiraterone Acetate Following Unresponsive Treatment With Diethylstilbestrol

2020-02-19 18:28:42 | BioPortfolio

Summary

The primary purpose of this study is to evaluate the influence of HSD3B1 (1245C) germline variant and potential pharmacodynamic markers on abiraterone activity in participants with metastatic castration-resistant prostate cancer after unresponsive use of diethylstilbestrol.

Study Design

Conditions

Metastatic Castration-resistant Prostate Cancer

Intervention

Serum and plasma samples analysis

Location

Sociedade Beneficiante de Senhoras - Hospital Sirio Libanes
São Paulo
Brazil
01308901

Status

Not yet recruiting

Source

Janssen-Cilag Farmaceutica Ltda.

Results (where available)

View Results

Links

Published on BioPortfolio: 2020-02-19T18:28:42-0500

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Medical and Biotech [MESH] Definitions

An androstene derivative that inhibits STEROID 17-ALPHA-HYDROXYLASE and is used as an ANTINEOPLASTIC AGENT in the treatment of metastatic castration-resistant PROSTATE CANCER.

Tumors or cancer of the PROSTATE which can grow in the presence of low or residual amount of androgen hormones such as TESTOSTERONE.

The simultaneous analysis, on a microchip, of multiple samples or targets arranged in an array format.

Proteins found in SEMEN. Major seminal plasma proteins are secretory proteins from the male sex accessory glands, such as the SEMINAL VESICLES and the PROSTATE. They include the seminal vesicle-specific antigen, an ejaculate clotting protein; and the PROSTATE-SPECIFIC ANTIGEN, a protease and an esterase.

The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.

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