Comparing the Effect of Sitagliptin/Metformin and Metformin in PCOS Patients

2020-02-19 18:28:44 | BioPortfolio


Investigators will evaluate and compare the efficacy of Sitagliptin/Metformin to metformin and sitagliptin on gdf9 and bmp15 gene expression on PCOS patients undergoing intracytoplasmic sperm injection(ICSI).


This study was conducted in Infertility clinic of Mahdiyeh Educational Hospital, Tehran. Patients in the four groups receive the drug 2 months before the start of the ovulation cycle, and treatment will continue until the day of the oocyte aspiration. The drug provide by midwife to patients and both patient and physician blind to the treatment regimen. The participants randomly divide into four groups.The ovulation induction stimulate with GnRh antagonist.

Study Design


Polycystic Ovary Syndrome


placebo, metformin, Sitagliptin, Sitagliptin/metformin


Mahdiyeh educational hospital
Iran, Islamic Republic of




Shahid Beheshti University of Medical Sciences

Results (where available)

View Results


Published on BioPortfolio: 2020-02-19T18:28:44-0500

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A pharmaceutical preparation of sitagliptin phosphate and metformin hydrochloride that is used in the treatment of TYPE 2 DIABETES.

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