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A Study to Evaluate Potential Cytochrome P450 and Transporter Protein Interactions With CC-99677

2020-02-17 18:20:49 | BioPortfolio

Summary

It is a phase 1, open-label, single-center, three-part study to assess the safety, tolerability, and pharmacokinetics of multiple doses of CC-99677 administered alone or in combination with either methotrexate and sulfasalazine; itraconazole, rifampin, midazolam, or a cocktail of digoxin, metformin, and rosuvastatin in healthy subjects

Description

This study will allow investigation of potential drug-drug interaction mediated through cytochrome P450 enzymes and drug transporter proteins. During each part, blood samples will be collected at prespecified times for pharmacokinetic assessments. Subject safety will be monitored throughout the study. There will be approximately 16 subjects enrolled into each part.

Study Design

Conditions

Healthy Volunteer

Intervention

CC-99677, Methotrexate, Sulfasalazine, Itraconazole, Rifampin, Midazolam, Digoxin, Metformin, Rosuvastatin

Location

Richmond Pharmacology Limited
London
United Kingdom
SW17 ORE

Status

Not yet recruiting

Source

Celgene

Results (where available)

View Results

Links

Published on BioPortfolio: 2020-02-17T18:20:49-0500

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