Study of AMG0001 to Improve Ulcer Healing and Perfusion in Subjects With Peripheral Ischemic Ulcers

2020-02-17 18:20:57 | BioPortfolio


This study will assess the safety and efficacy of intramuscular injection of AMG0001 (hepatocyte growth factor [HGF] plasmid) to improve ulcer healing and perfusion in patients with peripheral artery disease.


This is a Phase 2, double-blind, randomized, placebo-controlled, parallel group study. Approximately 60 male or female subjects aged 18 years or older with one shallow foot ulcer and mild/moderate ischemia due to peripheral artery disease (PAD) will be randomized in a 1:1:1 ratio to one of 3 treatment groups:

- 4.0 mg AMG0001 intramuscular (IM) (n = 20)

- 8.0 mg AMG0001 IM (n = 20)

- Placebo IM (n = 20)

Study Design


Peripheral Artery Disease


AMG0001, Placebo


Foot and Ankle Associates of Southwest Virginia
United States




AnGes USA, Inc.

Results (where available)

View Results


Published on BioPortfolio: 2020-02-17T18:20:57-0500

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