Comparative Effectiveness of CET vs. SST in SMI (Serious Mental Illness)

2020-03-28 03:55:26 | BioPortfolio


To compare two evidence-based treatments, Cognitive Enhancement Therapy (CET) and Social Skills Training (SST) that have been shown in meta-analyses and in our own research to be effective to improve community functioning. The investigators will test the impact of CET and SST on community functioning, with special attention to their relative effectiveness for patients differing in baseline cognitive skills and age. The research uses a cluster design in which different mental health service centers are randomized to one of the two treatments.


Aim 1. The investigators will test our hypothesis that CET will be associated with greater improvements than SST in both the primary outcome: community functioning (SAS, QLS), and the secondary outcomes of neuro- and social cognition (BACS and MSCEIT) and social skills (SSPA). . For study Aim 1,the investigators hypothesized that CET will be associated with greater improvements than SST in both the primary outcome: community functioning (SAS, QLS), and the secondary outcomes of neuro- and social cognition (NIH Toolbox and MSCEIT) and social skills (SSPA). Aim 2: The investigators will explore differential effectiveness of the two interventions by baseline cognitive functioning and age. For Aim 2, the investigators hypothesize that patients with less impairment in cognitive functioning at baseline will demonstrate relatively larger treatment gains in SST compared to those in CET than those who are initially more cognitively impaired, and that younger patients will benefit more from CET compared to those in SST than those who are older. The results of this study will address a key knowledge gap in the field and a decisional dilemma for clinicians.

Study Design


Schizophrenia and Related Disorders


Cognitive Enhancement Therapy, Social Skills Training


Beth Israel Deaconess Medical Center
United States


Not yet recruiting


Beth Israel Deaconess Medical Center

Results (where available)

View Results


Published on BioPortfolio: 2020-03-28T03:55:26-0400

Clinical Trials [7304 Associated Clinical Trials listed on BioPortfolio]

Cognitive Behavioral Social Skills Training for Patients With Late-Life Schizophrenia: a Pilot Study

Schizophrenia is associated with significant cognitive and functional deficits. As patients with schizophrenia grow older, the impact of these deficits at a personal and public health leve...

Cognitive Remediation and Social Skills Training in Schizophrenia

The purpose of this study is to examine whether patients who participate in cognitive remediation prior to a skills training program learn and perform the skills better than patients who d...

Integrated Cognitive Behavior Therapy to Improve Work Outcomes in Schizophrenia

Schizophrenia is associated with serious problems with cognitive skills, social skills, and functional skills (like employment). There is a new form of cognitive behavioral therapy called ...

Virtual Reality Training for Social Skills in Schizophrenia - Comparison With Cognitive Training

Social impairments are core features of schizophrenia that lead to poor outcome. Social skills and competence improve quality of life and protect against stress-related exacerbation of sym...

Functional Neuroimaging Effects of Cognitive Remediation Training

The purpose of this study is to examine behavioral and functional brain changes occuring as a result of cognitive remediation training in patients with schizophrenia. Extension and specif...

PubMed Articles [30280 Associated PubMed Articles listed on BioPortfolio]

Computerized cognitive remediation therapy, REHACOM, in first episode of schizophrenia: A randomized controlled trial.

Patients with schizophrenia show cognitive impairments that have been linked to poor social functioning. Computerized cognitive remediation therapy has shown to be effective in improving both cognitio...

Improving social functioning in community-dwelling patients with schizophrenia: a randomized controlled computer cognitive remediation therapy trial with six months follow-up.

Computerized cognitive remediation therapy (CCRT) has been found to generally improve cognition among patients with schizophrenia, but its effect on functioning has not been extensively studied. This ...

Evaluation of cognitive deficits in schizophrenia using event-related potentials and rehabilitation influences using EEG Biofeedback in patients diagnosed with schizophrenia.

Cognitive deficits in schizophrenic patients have a chronic and negative effect on patients' social functioning. Antipsychotic drugs do not sufficiently improve cognitive functions. In this study, an ...

Applying vinpocetine to reverse synaptic ultrastructure by regulating BDNF-related PSD-95 in alleviating schizophrenia-like deficits in rat.

Schizophrenia is a mental disorder characterized by hyperlocomotion, cognitive symptoms, and social withdrawal. Brain-derived neurotrophic factor (BDNF) and postsynaptic density (PSD)-95 are related t...

A randomized controlled trial of social skills training for patients with treatment-resistant schizophrenia with predominantly negative symptoms.

We conducted a randomized controlled trial to assess the effectiveness of social skills training (SST) in improving negative symptoms in patients with treatment-resistant schizophrenia with predominan...

Medical and Biotech [MESH] Definitions

The enhancement of physical, cognitive, emotional and social skills so an individual may participate in chosen activities. Recreational modalities are used in designed intervention strategies, incorporating individual's interests to make the therapy process meaningful and relevant.

Training of the mentally or physically disabled in work skills so they may be returned to regular employment utilizing these skills.

A personality trait rendering the individual acceptable in social or interpersonal relations. It is related to social acceptance, social approval, popularity, social status, leadership qualities, or any quality making him a socially desirable companion.

A direct form of psychotherapy based on the interpretation of situations (cognitive structure of experiences) that determine how an individual feels and behaves. It is based on the premise that cognition, the process of acquiring knowledge and forming beliefs, is a primary determinant of mood and behavior. The therapy uses behavioral and verbal techniques to identify and correct negative thinking that is at the root of the aberrant behavior.

A neuropsychological test designed to assess different memory functions. It may incorporate an optional cognitive exam (Brief Cognitive Status Exam) that helps to assess memory related cognitive function.

More From BioPortfolio on "Comparative Effectiveness of CET vs. SST in SMI (Serious Mental Illness)"

Quick Search

Relevant Topics

Mental Health
Adhd Anorexia Depression Dyslexia Mental Health Psychiatry Schizophrenia Stress Mental health, although not being as obvious as physical health, is very important, causing great unhappiness to those affected, causing add...

Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...

Searches Linking to this Trial