Topics

Urinary T Cell Biomarker for Prediction in Lupus Nephritis

2020-03-31 04:04:42 | BioPortfolio

Summary

Urinary effector memory T-lymphocytes may be predictive for clinical outcome in patients with lupus nephritis. The investigators hypothesize that the amount of CD4+ effector memory T cells in urine at time of diagnosis predicts the outcome of patients with active lupus nephritis (LN) after 6 months of therapy. In a prospective, six-months follow-up study patients' urine will be analysed by flow cytometry every 60 days (+/- 10d). Treatment will be performed to the discretion of the treating clinician. After 6 months of treatment response will be determined as either complete response or partial response.

Study Design

Conditions

Lupus Nephritis

Intervention

Flow cytometry analysis of urine samples

Location

Charité - Universitätsmedizin Berlin
Berlin
Germany
10117

Status

Recruiting

Source

Charite University, Berlin, Germany

Results (where available)

View Results

Links

Published on BioPortfolio: 2020-03-31T04:04:42-0400

Clinical Trials [2938 Associated Clinical Trials listed on BioPortfolio]

Safety and Efficacy on Deoxyspergualin (NKT-01) in Patients With Lupus Nephritis

The aim of the open multi-center study is to determine an efficient and safe dose and dosing schedule of NKT-01 in induction of response in treatment of lupus nephritis.

Pentoxifylline in Lupus Nephritis

This is a randomized, double-blind, placebo-controlled clinical trial of pentoxifylline or placebo, administered in addition to standard of care therapy for patients with lupus nephritis a...

Iguratimod as Treatment for Refractory Lupus Nephritis

This study is to evaluate the efficacy and safety of a novel chemical synthetic agent iguratimod as treatment of refractory lupus nephritis. All subjects should have at least one failed im...

Induction Treatment of Proliferative Lupus Nephritis With Leflunomide Combined With Prednisone

lupus nephritis accounts for the most morbidity and mortality in patients with SLE. Glucocorticoids combined with cyclophosphamide (CYC) are effective for the treatment of patients with pr...

The Correlation of Periostin and Renal Pathology in Chronic Kidney Disease Patients

The purpose of this study is to determine the location of periostin and urine periostin level in patients with lupus nephritis and IgA nephropathy.

PubMed Articles [22738 Associated PubMed Articles listed on BioPortfolio]

Serum Levels of CXCL10 and Vitamin D in Patients with Lupus Nephritis.

Kidney involvement is a hallmark of systemic lupus erythematosus (SLE) and evaluation of its inflammatory response is demanding. It was the aim of the present study to evaluate the levels of CXCL10 an...

Comparison of Different Usage of Cyclophosphamide in Lupus Nephritis: A Meta-analysis of Randomized Controlled Trails.

The present study aims to compare the relative efficacy and safety of different usage of cyclophosphamide (CYC) in lupus nephritis (LN).

Immune cell infiltration characteristics and related core genes in lupus nephritis: results from bioinformatic analysis.

Lupus nephritis (LN) is a common complication of systemic lupus erythematosus that presents a high risk of end-stage renal disease. In the present study, we used CIBERSORT and gene set enrichment anal...

Initial renal histology and early response predict outcomes of Brazilian lupus nephritis patients.

We analyzed baseline and follow-up characteristics related to poorer renal outcomes in a Brazilian cohort of admixture race patients with lupus nephritis.

Role of A20/TNFAIP3 deficiency in lupus nephritis in MRL/lpr mice.

The activation of the nuclear factor-κB (NF-κB) signaling pathway gives rise to inflammation in the pathogenesis of lupus nephritis (LN), with A20 serving as a negative feedback regulator and ubiqui...

Medical and Biotech [MESH] Definitions

Glomerulonephritis associated with autoimmune disease SYSTEMIC LUPUS ERYTHEMATOSUS. Lupus nephritis is histologically classified into 6 classes: class I - normal glomeruli, class II - pure mesangial alterations, class III - focal segmental glomerulonephritis, class IV - diffuse glomerulonephritis, class V - diffuse membranous glomerulonephritis, and class VI - advanced sclerosing glomerulonephritis (The World Health Organization classification 1982).

A technique encompassing morphometry, densitometry, neural networks, and expert systems that has numerous clinical and research applications and is particularly useful in anatomic pathology for the study of malignant lesions. The most common current application of image cytometry is for DNA analysis, followed by quantitation of immunohistochemical staining.

Methods or procedures used to obtain samples of URINE.

The simultaneous analysis, on a microchip, of multiple samples or targets arranged in an array format.

The simultaneous analysis of multiple samples of TISSUES or CELLS from BIOPSY or in vitro culture that have been arranged in an array format on slides or microchips.

More From BioPortfolio on "Urinary T Cell Biomarker for Prediction in Lupus Nephritis"

Quick Search

Relevant Topics

Urology
Benign Prostatic Hyperplasia (BPH) Erectile Dysfunction Urology Urology is the branch of medicine concerned with the urinary tract and diseases that affect it. Examples include urethritis, urethrostenosis and incontinence. Urology is a su...

Blood
Blood is a specialized bodily fluid that delivers necessary substances to the body's cells (in animals) – such as nutrients and oxygen – and transports waste products away from those same cells.  In vertebrates, it is composed of blo...

Rheumatology
Arthritis Fibromyalgia Gout Lupus Rheumatic Rheumatology is the medical specialty concerned with the diagnosis and management of disease involving joints, tendons, muscles, ligaments and associated structures (Oxford Medical Diction...


Searches Linking to this Trial