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Comparison of Pulsed-field Gel Electrophoresis and Whole Genome Sequencing to Determine Transmission Rate of ESBL-producing E.Coli

2020-04-01 04:26:51 | BioPortfolio

Summary

The aim of this quality control study is to compare two different techniques to determine ESBL-producing E.coli transmission.

Study Design

Conditions

Analysis Transmission Rate

Intervention

Pulsed-field gel electrophoresis and whole genome sequencing, Data collection

Location

University Hospital Basel, Division of Infectious Diseases and Hospital Epidemiology
Basel
Switzerland
4031

Status

Active, not recruiting

Source

University Hospital, Basel, Switzerland

Results (where available)

View Results

Links

Published on BioPortfolio: 2020-04-01T04:26:51-0400

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Medical and Biotech [MESH] Definitions

Electrophoresis in which the direction of the electric field is changed periodically. This technique is similar to other electrophoretic methods normally used to separate double-stranded DNA molecules ranging in size up to tens of thousands of base-pairs. However, by alternating the electric field direction one is able to separate DNA molecules up to several million base-pairs in length.

Using MOLECULAR BIOLOGY techniques, such as DNA SEQUENCE ANALYSIS; PULSED-FIELD GEL ELECTROPHORESIS; and DNA FINGERPRINTING, to identify, classify, and compare organisms and their subtypes.

A field of biology concerned with the development of techniques for the collection and manipulation of biological data, and the use of such data to make biological discoveries or predictions. This field encompasses all computational methods and theories applicable to MOLECULAR BIOLOGY and areas of computer-based techniques for solving biological problems including manipulation of models and datasets.

Techniques to determine the entire sequence of the GENOME of an organism or individual.

Systematic gathering of data for a particular purpose from various sources, including questionnaires, interviews, observation, existing records, and electronic devices. The process is usually preliminary to statistical analysis of the data.

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