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Effects of Sitagliptin in Individuals With Genetically Decreased DPP4

2020-04-01 04:26:53 | BioPortfolio

Summary

This is a pilot clinical trial to test the hypothesis that during sitagliptin (DPP4 inhibitor), individuals heterozygous for DPP4 loss of function variants will have a reduction in DPP4 activity and antigen, lower glucose after a mixed meal, and higher levels of intact DPP4 substrates compared to during placebo and compared to matched controls.

Description

Participants of this pilot clinical trial will be randomized in a blinded 2:2 crossover manner to receive placebo and sitagliptin 100 mg/d (DPP4 inhibitor), in random order. Subjects will receive each intervention for seven days, with a study day on day 7. Each intervention will be separated by a 4-week washout period. Each subject will have up to four separate visits: 1) DXA, echocardiogram, 2) cardiac MRI, 3) mixed meal during placebo, 4) mixed meal during sitagliptin.

The study will include 10 cases and 10 controls. Among these, there will be five heterozygous cases and five matched controls with elevated blood pressure (history of blood pressure 130/80 on more than one occasion or prior diagnosis of hypertension by a medical provider) and five cases and five controls without hypertension.

Study Design

Conditions

Genetics Disease

Intervention

Sitagliptin 100mg, Placebo Oral Tablet

Location

University of Pennsylvania
Philadelphia
Pennsylvania
United States
19104

Status

Suspended

Source

University of Pennsylvania

Results (where available)

View Results

Links

Published on BioPortfolio: 2020-04-01T04:26:53-0400

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