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Treatment of Moderate to Severe Coronavirus Disease (COVID-19) in Hospitalized Patients

2020-03-31 04:03:57 | BioPortfolio

Summary

Investigational medications adjunct to clinical standard of care treatment will be assessed to evaluate safety and effectiveness as an anti-COVID-19 treatment. All hospitalized persons with moderate to severe COVID-19 disease that meet eligibility criteria will be offered participation.

Study Design

Conditions

COVID-19

Intervention

Lopinavir/ritonavir, Hydroxychloroquine sulfate, Baricitinib (janus kinase inhibitor), Sarilumab (anti-IL-6 receptor)

Status

Not yet recruiting

Source

Nova Scotia Health Authority

Results (where available)

View Results

Links

Published on BioPortfolio: 2020-03-31T04:03:57-0400

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Medical and Biotech [MESH] Definitions

An HIV protease inhibitor used in a fixed-dose combination with RITONAVIR. It is also an inhibitor of CYTOCHROME P-450 CYP3A.

A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.

A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS. The TYK2 kinase is considered the founding member of the janus kinase family and was initially discovered as a signaling partner for the INTERFERON ALPHA-BETA RECEPTOR. The kinase has since been shown to signal from several INTERLEUKIN RECEPTORS.

A Janus kinase subtype that is involved in signaling from a broad variety of CYTOKINE RECEPTORS.

A Janus kinase subtype that is predominantly expressed in hematopoietic cell. It is involved in signaling from a broad variety of CYTOKINE RECEPTORS including ones that utilize the INTERLEUKIN RECEPTOR COMMON GAMMA SUBUNIT.

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