Argatroban for Preventing Occlusion and Restenosis After Intracranial and Extracranial Artery Stenting

2014-08-27 03:12:10 | BioPortfolio


The risk of restenosis post intracranial and extracranial artery stenting is 20-40%, therefore, in the past, aspirin and clopidogrel were performed as anticoagulant therapy post stenting.But this treatment had limited effectiveness upon restenosis. Argatroban is a selective thrombin inhibitor, and previous study had suggested that argatroban use post PCI could potentially prevent reocclusion. But there has no study on large sample of argatroban treated restenosis post cranial stenting. This study will test the safety and efficacy of the argatroban on prevent occlusion and restenosis in patients with intracranial and extracranial artery stenting.

Study Design

Allocation: Randomized, Control: Uncontrolled, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment




Argatroban, non-argatroban treated group


Department of Neurology, Jinling Hospital, Nanjing University School of Medicine


Not yet recruiting


Jinling Hospital, China

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:12:10-0400

Clinical Trials [289 Associated Clinical Trials listed on BioPortfolio]

Study on Safety and Effectiveness of Three Doses of Argatroban as Anticoagulant in Percutaneous Coronary Intervention (PCI)

This is a phase II multi-centre study in 140 patients undergoing elective PCI to obtain the information on dose-response of argatroban in pharmacodynamic markers and to assess the anticoag...

Argatroban Versus Lepirudin in Critically Ill Patients

The purpose of this study is to test the hypotheses that argatroban significantly increases efficacy and safety of renal replacement therapy measured as life time of haemodialysis filters ...

A Comparative Sudy Comparing Argatroban® IV vs Desirudin SC for Suspected HIT With or Without Thrombosis Syndrome

Compare Clinical Success and Costs in two Arms

Evaluation of Argatroban Injection in Pediatric Patients Requiring Anticoagulant Alternatives to Heparin

The purpose of this study is to evaluate the safe and effective dose of Argatroban for prophylaxis and/or treatment of thrombosis in pediatric patients with current or previous diagnosis o...

Argatroban TPA Stroke Study

Is the combination of low doses of argatroban in combination with rt-PA safe, and does it increase recanalization in patients with acute ischemic stroke.

PubMed Articles [12229 Associated PubMed Articles listed on BioPortfolio]

Safety and Feasibility of using Argatroban immediately after mechanical thrombectomy for large artery occlusion.

This study aims to evaluate the safety and effects of using argatroban, immediately after mechanical thrombectomy (MT) with large artery occlusion.

Lipopolysaccharide-Induced Hemolysis Is Abolished by Inhibition of Thrombin Generation but Not Inhibition of Platelet Aggregation.

In human sepsis, hemolysis is an independent predictor of mortality, but the mechanisms evoking hemolysis have not been fully elucidated. Therefore, we tested the hypotheses that (1) lipopolysaccharid...

A novel medical device coating prevents Staphylococcus aureus biofilm formation on medical device surfaces.

Prevention of device related infections due to Staphylococcus aureus biofilms on devices represents a significant challenge. Such infections have recently been shown to be dependent on the coagulation...

Evaluation of the cardioprotective effect of extract in rats.

The aim of the current study was to examine and compare the cardioprotective activities of the chloroform and petroleum extracts the leaves of in isoproterenol (ISO)-induced cardiac tissue oxidative ...

Application of thrombelastography in primary total knee and total hip replacement: a prospective 87 patients study.

: Thrombelastography (TEG) parameters and prothrombin time (PT), activated partial thromboplastin time (APTT) are compared and analysed. According to change of TEG parameters and assessment of haemost...

Medical and Biotech [MESH] Definitions

A group of conditions due to overexposure to or overexertion in excess environmental temperature. It includes heat cramps, which are non-emergent and treated by salt replacement; HEAT EXHAUSTION, which is more serious, treated with fluid and salt replacement; and HEAT STROKE, a condition most commonly affecting extremes of age, especially the elderly, accompanied by convulsions, delusions, or coma and treated with cooling the body and replacement of fluids and salts. (From Segen, Dictionary of Modern Medicine, 1992)

The process by which a person or group of persons comes to be regarded or treated as lacking in human qualities.

A large group of rod-shaped bacteria that retains the crystal violet stain when treated by Gram's method.

A system of therapeutics founded by Samuel Hahnemann (1755-1843), based on the Law of Similars where "like cures like". Diseases are treated by highly diluted substances that cause, in healthy persons, symptoms like those of the disease to be treated. The dilutions are repeated so many times that there is less than one molecule per dose and it is suggested that benefit is from the energetic life force of the original substance.

A group of anaerobic coccoid bacteria that show up as pink (negative) when treated by the gram-staining method.

More From BioPortfolio on "Argatroban for Preventing Occlusion and Restenosis After Intracranial and Extracranial Artery Stenting"

Quick Search

Relevant Topic

Neurology - Central Nervous System (CNS)
Alzheimer's Disease Anesthesia Anxiety Disorders Autism Bipolar Disorders Dementia Epilepsy Multiple Sclerosis (MS) Neurology Pain Parkinson's Disease Sleep Disorders Neurology is the branch of me...

Searches Linking to this Trial