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Efficacy of Helicobacter Pylori Eradication, Anti-D and Danazol Combination in Steroid Dependant or Refractory Immune Thrombocytopenia (ITP)

2014-07-23 21:08:14 | BioPortfolio

Summary

Proportion who would avoid splenectomy at 6 months of follow up

Description

1. If urea breath test (+); omeprazole 20mg bid, amoxicillin 1000mg bid and clarithromycin 500mg bid for 1 week.

Second line Helicobacter pylori eradication will be permitted after failure of first line treatment.

2. Anti-D Anti-Ro 50 μg/kg IV for 2 days (D1, 2)

3. Danazol maintenance (from D1): Danazol will be continued at least 3 months. The dose of danazol can be reduced according to the adverse effects, especially in premenopausal women.

Study Design

Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Thrombocytopenia

Intervention

Steroid refractory ITP

Location

Asan Medical Center
Seoul
Asanbyeongwon-gil, songpa-gu
Korea, Republic of
138-736

Status

Recruiting

Source

Cooperative Study Group A for Hematology

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:08:14-0400

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