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Oral Polypodium Leucotomos for Melasma

2014-08-27 03:12:11 | BioPortfolio

Summary

Primary Objective: To determine whether there is improvement in the melasma of participants taking oral Polypodium Leucotomos Secondary Objective: To determine whether oral Polypodium Leucotomos is well tolerated in study subjects with melasma.

To determine whether treatment with Polypodium Leucotomos improves the HRQoL

Description

Polypodium Leucotomos is a fern, also known as Calaguala used by the natives of northern Honduras as a treatment against malignant tumors Used in Spain and Central America for the treatment of psoriasis, atopic dermatitis and repigmentation of vitiligo.

Oral Polypodium Leucotomos is safe and effective in patients with melasma.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment

Conditions

Melasma

Intervention

Polypodium Leucotomos, Placebo

Location

University of Miami Cosmetic Center
Miami
Florida
United States
33140

Status

Completed

Source

University of Miami

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:11-0400

Clinical Trials [27 Associated Clinical Trials listed on BioPortfolio]

Single-Blind Study Determining the Efficacy of Polypodium Leucotomos Extract Supplement in Decreasing Ultraviolet A (UVA) Premutagenic and Photoaging Markers

With this study we will like to determine if taking a dose of the study medication, called Polypodium leucotomos (PL), prevents some of the changes in the skin caused by the adverse effect...

Platelet Rich Plasma in Treatment of Melasma

Melasma is a common acquired disorder characterized by symmetric, hyperpigmented patches with an irregular outline, occurring most commonly on the face. The therapy for melasma has always ...

Prevalence of Serum-Vitamin D Abnormalities, Periodontitis and Anaemia in Patients With Melasma

Melasma is a commonly acquired, pigmentary disorder characterized by symmetric melanosis of the face. The relation between vitamin D deficiency and periodontitis have been evaluated and re...

Melanil in the Treatment of Melasma

The purpose of the study is to assess the efficacy of Melanil facial cream in the treatment of melasma. The duration of this double-blind phase 3 clinical trial will be 54 weeks. The contr...

Oral and Topical Tranexamic Acid for the Treatment of Melasma

Tranexamic acid has been used for treating melasma due to its effect on decreasing the activity of tyrosinase and melanogenesis. This 3-arm clinical trial will asess the efficacy and safet...

PubMed Articles [911 Associated PubMed Articles listed on BioPortfolio]

Double Blind, Placebo Controlled Evaluation of a Novel Skin Lightening Agent.

Melasma remains a troubling problem for physicans and patients alike. It is a chronic irregular, symmetric hyperpigmentation seen most often in women. In this study, a unique combination of ingredient...

Development and validation of a multidimensional questionnaire for evaluating quality of life in melasma (HRQ-melasma).

Melasma has a major impact on quality of life. MELASQoL is the only validated specific psychometric instrument to evaluate melasma QoL.

Exploring pathways for sustained melanogenesis in facial melasma: an immunofluorescence study.

The physiopathology of epidermal hypermelanization in melasma is not completely understood. Several cytokines and growth factors are increased in skin with melasma, nevertheless, nor the pathways invo...

Oral Tranexamic Acid for the Treatment of Melasma: A Review.

Melasma is a common acquired disorder of hyperpigmentation that commonly affects those with skin of color. Tranexamic acid (TXA) is a novel treatment for melasma that has a multimodal mechanism of act...

Treatment of melasma using tranexamic acid: what's known and what's next.

Tranexamic acid is a procoagulant agent that is approved by the US Food and Drug Administration for treatment of menorrhagia and to prevent hemorrhage in patients with hemophilia undergoing tooth extr...

Medical and Biotech [MESH] Definitions

A plant genus of the family POLYPODIACEAE. Members contain polypodoside.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

A plant genus of the family Pteridaceae. Members contain TRITERPENES. Some species in this genus are called maidenhair fern which is also a common name occasionally used for Lygodium (FERNS) and POLYPODIUM.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

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