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Oral Polypodium Leucotomos for Melasma

2014-08-27 03:12:11 | BioPortfolio

Summary

Primary Objective: To determine whether there is improvement in the melasma of participants taking oral Polypodium Leucotomos Secondary Objective: To determine whether oral Polypodium Leucotomos is well tolerated in study subjects with melasma.

To determine whether treatment with Polypodium Leucotomos improves the HRQoL

Description

Polypodium Leucotomos is a fern, also known as Calaguala used by the natives of northern Honduras as a treatment against malignant tumors Used in Spain and Central America for the treatment of psoriasis, atopic dermatitis and repigmentation of vitiligo.

Oral Polypodium Leucotomos is safe and effective in patients with melasma.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Safety/Efficacy Study, Intervention Model: Parallel Assignment, Masking: Double Blind (Subject, Caregiver), Primary Purpose: Treatment

Conditions

Melasma

Intervention

Polypodium Leucotomos, Placebo

Location

University of Miami Cosmetic Center
Miami
Florida
United States
33140

Status

Completed

Source

University of Miami

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:11-0400

Clinical Trials [31 Associated Clinical Trials listed on BioPortfolio]

Single-Blind Study Determining the Efficacy of Polypodium Leucotomos Extract Supplement in Decreasing Ultraviolet A (UVA) Premutagenic and Photoaging Markers

With this study we will like to determine if taking a dose of the study medication, called Polypodium leucotomos (PL), prevents some of the changes in the skin caused by the adverse effect...

Identification of Biomarkers and Characterization of Melasma

Melasma (also called chloasma and pregnancy mask) is characterized by pigmented lesions darker than their usual complexion on the faces of affected subjects. The physiopathology of melasm...

Platelet Rich Plasma in Treatment of Melasma

Melasma is a common acquired disorder characterized by symmetric, hyperpigmented patches with an irregular outline, occurring most commonly on the face. The therapy for melasma has always ...

Prevalence of Serum-Vitamin D Abnormalities, Periodontitis and Anaemia in Patients With Melasma

Melasma is a commonly acquired, pigmentary disorder characterized by symmetric melanosis of the face. The relation between vitamin D deficiency and periodontitis have been evaluated and re...

Melanil in the Treatment of Melasma

The purpose of the study is to assess the efficacy of Melanil facial cream in the treatment of melasma. The duration of this double-blind phase 3 clinical trial will be 54 weeks. The contr...

PubMed Articles [891 Associated PubMed Articles listed on BioPortfolio]

Development and validation of a multidimensional questionnaire for evaluating quality of life in melasma (HRQ-melasma).

Melasma has a major impact on quality of life. MELASQoL is the only validated specific psychometric instrument to evaluate melasma QoL.

A Randomized, Double-Blind, Placebo-Controlled, Split-Face Study of the Efficacy of Topical Epidermal Growth Factor for the Treatment of Melasma.

Melasma is a condition in which patients develop symmetric, reticulated, hyperpigmented macules and patches on the face which is thought to be the result of ultraviolet (UV) exposure and hormonal infl...

Exploring pathways for sustained melanogenesis in facial melasma: an immunofluorescence study.

The physiopathology of epidermal hypermelanization in melasma is not completely understood. Several cytokines and growth factors are increased in skin with melasma, nevertheless, nor the pathways invo...

A Biologically Based Approach to Acne and Rosacea.

Complementary and alternative medicine (CAM) therapies are increasing in popularity in the field of dermatology. Natural products and holistic approaches are in high demand among patients and research...

Using reflectance confocal microscopy to observe in vivo melanolysis after treatment with the picosecond alexandrite laser and Q-switched Nd:YAG laser in melasma.

Melasma is an acquired type of hyperpigmentation that is characterized by the appearance of scattered light- to dark-brown macules and patches on the face. Recently, several lasers have been proposed ...

Medical and Biotech [MESH] Definitions

A plant genus of the family POLYPODIACEAE. Members contain polypodoside.

Misunderstanding among individuals, frequently research subjects, of scientific methods such as randomization and placebo controls.

A plant genus of the family Pteridaceae. Members contain TRITERPENES. Some species in this genus are called maidenhair fern which is also a common name occasionally used for Lygodium (FERNS) and POLYPODIUM.

An effect usually, but not necessarily, beneficial that is attributable to an expectation that the regimen will have an effect, i.e., the effect is due to the power of suggestion.

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