Latanoprost Versus Tafluprost: 24-hour Intraocular Pressure (IOP)

2014-08-27 03:12:11 | BioPortfolio


- Main objective is to compare the ability of Latanoprost 0.005% preservative-added ophthalmic solution versus Tafluprost 0.0015% preservative-free ophthalmic solution, both given once a day at the evening, in reducing 24-hour intraocular pressure (IOP) in patients with primary open angle glaucoma (POAG) and/or ocular hypertension (OHT) at first diagnosis. First efficacy variable will be the difference between mean nocturnal IOP values after three months of treatment: nocturnal IOP is defined as the mean value between 2AM and 6AM measurements.

- Secondary objectives will be the comparison between Latanoprost 0.005% and Tafluprost 0.0015% ophthalmic solution about:

- Mean 24-hour IOP values after three months of treatment

- IOP values at these time-points: 10AM (± 1 hour), 2PM (± 1 hour), 6PM (± 1 hour), 10PM (± 1 hour), 2AM (± 1 hour) and 6AM (± 1 hour) after three months of treatment

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment


Primary Open Angle Glaucoma


Goldmann and Perkins applanation tonometry, TAFLUPROST 0.0015% EYEDROPS, LATANOPROST 0.005% EYEDROPS


USVD "Centro per lo studio del Glaucoma" Spedali Civili di Brescia


Not yet recruiting


Azienda Ospedaliera Spedali Civili di Brescia

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:12:11-0400

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