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Latanoprost Versus Tafluprost: 24-hour Intraocular Pressure (IOP)

2014-08-27 03:12:11 | BioPortfolio

Summary

- Main objective is to compare the ability of Latanoprost 0.005% preservative-added ophthalmic solution versus Tafluprost 0.0015% preservative-free ophthalmic solution, both given once a day at the evening, in reducing 24-hour intraocular pressure (IOP) in patients with primary open angle glaucoma (POAG) and/or ocular hypertension (OHT) at first diagnosis. First efficacy variable will be the difference between mean nocturnal IOP values after three months of treatment: nocturnal IOP is defined as the mean value between 2AM and 6AM measurements.

- Secondary objectives will be the comparison between Latanoprost 0.005% and Tafluprost 0.0015% ophthalmic solution about:

- Mean 24-hour IOP values after three months of treatment

- IOP values at these time-points: 10AM (± 1 hour), 2PM (± 1 hour), 6PM (± 1 hour), 10PM (± 1 hour), 2AM (± 1 hour) and 6AM (± 1 hour) after three months of treatment

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Crossover Assignment, Masking: Single Blind (Investigator), Primary Purpose: Treatment

Conditions

Primary Open Angle Glaucoma

Intervention

Goldmann and Perkins applanation tonometry, TAFLUPROST 0.0015% EYEDROPS, LATANOPROST 0.005% EYEDROPS

Location

USVD "Centro per lo studio del Glaucoma" Spedali Civili di Brescia
Brescia
Italy
25123

Status

Not yet recruiting

Source

Azienda Ospedaliera Spedali Civili di Brescia

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:11-0400

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