Advertisement

Topics

Assessment and Monitoring of Patients in Medium-term Heart Transplant Candidates Undergoing Low-intensity Exercise

2014-07-24 14:00:42 | BioPortfolio

Summary

Objectives: To study the behavior and cardiovascular safety protocol to the front low-intensity exercise in patients with heart failure (HF) severe, awaiting heart transplantation. Methods: The investigators studied 21 patients with severe HF on the list for a heart transplant at the University Hospital of UNIFESP. After evaluation, patients underwent exercise protocol with six stages of exercise (1. upper limbs, 2. inferiors, 3. walk 35 m, 4. ½ flight of stairs, 5. walk 200 m 6. a flight of stairs) with intensity between 2-6 metabolic equivalents. These also were followed for an average period of 17 months as the clinical complications and death. Results: From the patients studied, three were not able to perform the full protocol, and the variables body mass index, maximal inspiratory and expiratory pressure measurement (Pimáx and Pemáx, cmH2O) and number of previous admissions, showed the most divergent behavior of the sample studied. A greater increase in heart rate, double product and scale of perceived exertion during step 5 was observed during the protocol. Blood pressure levels showed little change between stages, and there was no arrhythmias incidence increase (kappa = 0.552) compared to effort. A positive correlation scale was perceived in exertion walking distance of 200m, with systolic blood pressure (r = 0.4, p = 0.02). Overall observed lower values of maximal inspiratory pressure and increased blood pressure and elevated heart rate in patients with death outcome. Conclusion: Cardiovascular behavior against exercise protocol was well tolerated and safe, but suggests need for monitoring. Information collected at initial clinical evaluation associated with decompensation and death, and may help stratify these patients.

Study Design

Endpoint Classification: Safety Study, Intervention Model: Single Group Assignment, Primary Purpose: Supportive Care

Conditions

Heart Failure

Intervention

low intensity exercise

Location

Federal University of Sao Paulo
Sao paulo
Brazil
04023-002

Status

Completed

Source

Federal University of São Paulo

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-24T14:00:42-0400

Clinical Trials [4405 Associated Clinical Trials listed on BioPortfolio]

High-Intensity Exercise Training in Patients With Post-Infarction Heart Failure

Introduction: Moderate-intensity endurance-training is known to reduce symptoms, increase exercise tolerance, and improve quality of life in patients with chronic heart failure. The traini...

High-intensity vs. Low-intensity Inspiratory Muscle Training in Patients With Heart Failure

It is well-known that muscle weakness and deconditioning play an important role in low exercise capacity of patients with HF. Interestingly, not only peripheral muscles are impaired, but a...

The Effect of Two Exercise Training Protocols on Physiological and Biochemical Parameters in Congestive Heart Failure

The aim of the present study is to evaluate differential lactate removal kinetics in heart failure patients that are trained according to 2 different exercise protocols: (A) High intensi...

Exercise Training in Patients With Atrial Fibrillation (OPPORTUNITY Study)

Atrial fibrillation is the most common heart rhythm disorder. The management of atrial fibrillation is of great importance. Despite the presence of exercise intolerance, weight gain, and a...

Effect of mechanIcal circulatoRy Support ON Exercise Capacity aMong pAtieNts With Heart Failure

This study will evaluate how the cardiovascular system interacts with mechanical hearts to provide blood flow to the body during exercise. Two aims are proposed: 1) to determine the impact...

PubMed Articles [10414 Associated PubMed Articles listed on BioPortfolio]

Meta-Analysis of Exercise Training on Left Ventricular Ejection Fraction in Heart Failure with Reduced Ejection Fraction: A 10-Year Update.

The role of exercise training modality to attenuate left ventricular (LV) remodeling in heart failure patients with reduced ejection fraction (HFrEF) remains uncertain. The authors performed a systema...

Alveolar air and O uptake during exercise in patients with heart failure.

Peak exercise V̇O is a primary marker of prognosis in heart failure (HF). The pathophysiology of impaired peak V̇O is unclear in patients. To what extent alveolar airway function impacts V̇O during...

Exercise training workloads in cardiac rehabilitation are associated with clinical outcomes in patients with heart failure.

In patients with coronary heart disease, the exercise workload (i.e., metabolic equivalents of task, METs) at which patients exercise train upon entry and completion of cardiac rehabilitation (CR) are...

Impact of a Graded Exercise Program on VO2peak and Survival in Heart Failure Patients.

Although exercise therapy has the potential to improve health outcomes of patients with Chronic Heart Failure (CHF), less than 50% of patients adhere to prescribed physical activity guidelines one yea...

Ischaemic aetiology predicts exercise dyssynchrony in patients with heart failure with reduced ejection fraction.

Left ventricular (LV) dyssynchrony is common in patients with heart failure with reduced ejection fraction (HFREF). However, various conditions including exercise may alter its presence. LV dyssynchro...

Medical and Biotech [MESH] Definitions

Controlled physical activity, more strenuous than at rest, which is performed in order to allow assessment of physiological functions, particularly cardiovascular and pulmonary, but also aerobic capacity. Maximal (most intense) exercise is usually required but submaximal exercise is also used. The intensity of exercise is often graded, using criteria such as rate of work done, oxygen consumption, and heart rate.

A heterogeneous condition in which the heart is unable to pump out sufficient blood to meet the metabolic need of the body. Heart failure can be caused by structural defects, functional abnormalities (VENTRICULAR DYSFUNCTION), or a sudden overload beyond its capacity. Chronic heart failure is more common than acute heart failure which results from sudden insult to cardiac function, such as MYOCARDIAL INFARCTION.

Enlargement of the HEART, usually indicated by a cardiothoracic ratio above 0.50. Heart enlargement may involve the right, the left, or both HEART VENTRICLES or HEART ATRIA. Cardiomegaly is a nonspecific symptom seen in patients with chronic systolic heart failure (HEART FAILURE) or several forms of CARDIOMYOPATHIES.

A cardiovascular exercise strategy with alternating short periods of intense anaerobic exercise with less-intense recovery periods.

Heart failure caused by abnormal myocardial contraction during SYSTOLE leading to defective cardiac emptying.

More From BioPortfolio on "Assessment and Monitoring of Patients in Medium-term Heart Transplant Candidates Undergoing Low-intensity Exercise"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Cardiology
Cardiology is a specialty of internal medicine.  Cardiac electrophysiology : Study of the electrical properties and conduction diseases of the heart. Echocardiography : The use of ultrasound to study the mechanical function/physics of the h...

Cardiovascular disease (CVD)
Acute Coronary Syndromes (ACS) Blood Cardiovascular Dialysis Hypertension Stent Stroke Vascular Cardiovascular disease (CVD) includes all the diseases of the heart and circulation including coronary heart disease (angina...


Searches Linking to this Trial