Human Papillomavirus (HPV) Vaccination in Barretos (Pio XII Foundation - Barretos Cancer Hospital)

2014-08-27 03:12:18 | BioPortfolio


PROJECT JUSTIFICATION Cervical cancer is a serious public health problem in Brazil, and is the cause of significant morbidity and mortality among Brazilian women. In spite of government efforts to improve the coverage rates of Pap tests, the disease-related incidence and mortality rates remain high and the diagnosis is still too late.

Considering that the chronic human papillomavirus (HPV) related genital infection leads to cervical cancer development, cervical cancer should be the target of primary prevention through vaccination. Although the Food and Drug Administration (FDA) and Agência Nacional de Vigilância Sanitária (ANVISA) have already approved the use of the HPV vaccine, it is not included in the PNI - Programa Nacional de Imunização (National Immunization Program) in Brazil so far.

The implementation of an HPV vaccination program in the country is a significant challenge to managers. In addition to financial issues, there are doubts about the ideal age bracket for vaccination and the best manner to adhere to the program. Also, there is a fear that the vaccine may adversely affect the cervical cancer screening program.


1. Evaluating the knowledge about the Pap test, cervical cancer, HPV, and vaccine in vaccinated girls and mothers (or legally responsible individuals) - before and after the vaccine program;

2. Evaluating the vaccination program recruiting rate (school-based program);

3. Evaluating adherence to the vaccination program.

TARGET POPULATION Women domiciled in Barretos aged 12 and 13 years.

VACCINATION PROGRAM The program will adopt the quadrivalent vaccine because it is considered superior to the bivalent vaccine in preventing HPV-induced lesions. In addition to preventing the development of pre-cancer lesions and cervical cancer, the quadrivalent vaccine has also proved to be effective in preventing condyloma, and vaginal and vulvar cancer. The girls will receive the vaccines doses at their schools (school-based program).

Study Design

Observational Model: Cohort, Time Perspective: Prospective


Human Papillomavirus


Not yet recruiting


Barretos Cancer Hospital

Results (where available)

View Results


Published on BioPortfolio: 2014-08-27T03:12:18-0400

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Medical and Biotech [MESH] Definitions

A type of human papillomavirus especially associated with malignant tumors of the genital and RESPIRATORY MUCOSA.

Vaccines or candidate vaccines used to prevent PAPILLOMAVIRUS INFECTIONS. Human vaccines are intended to reduce the incidence of UTERINE CERVICAL NEOPLASMS, so they are sometimes considered a type of CANCER VACCINES. They are often composed of CAPSID PROTEINS, especially L1 protein, from various types of ALPHAPAPILLOMAVIRUS.

ONCOGENE PROTEINS from papillomavirus that deregulate the CELL CYCLE of infected cells and lead to NEOPLASTIC CELL TRANSFORMATION. Papillomavirus E7 proteins have been shown to interact with various regulators of the cell cycle including RETINOBLASTOMA PROTEIN and certain cyclin-dependent kinase inhibitors.

A vaccine containing L1 capsid proteins from four types of HPV (ALPHAPAPILLOMAVIRUS), types 6, 11, 16 and 18 that is used to prevent infections from HUMAN PAPILLOMAVIRUSES of these subtypes.


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