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A Clinical Trial to Evaluate the Safety, Tolerability and Preliminary Effectiveness of Single Administration Intradiscal rhGDF-5 for the Treatment of Early Stage Lumbar Disc Degeneration

2014-07-23 21:08:29 | BioPortfolio

Summary

Study to show the safety, tolerability and preliminary effectiveness of Intradiscal rhGDF-5 in subjects with early lumbar disc degeneration.

Study Design

Intervention Model: Single Group Assignment, Masking: Open Label

Conditions

Early Lumbar Disc Degeneration

Intervention

Intradiscal rhGDF-5

Location

Hunter Clinical Research
Broadmeadow
New South Wales
Australia
2292

Status

Recruiting

Source

Advanced Technologies and Regenerative Medicine, LLC (ATRM)

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:08:29-0400

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Medical and Biotech [MESH] Definitions

The replacement of intervertebral discs in the spinal column with artificial devices. The procedure is done in the lumbar or cervical spine to relieve severe pain resulting from INTERVERTEBRAL DISC DEGENERATION.

An INTERVERTEBRAL DISC in which the NUCLEUS PULPOSUS has protruded through surrounding ANNULUS FIBROSUS. This occurs most frequently in the lower lumbar region.

Degenerative changes in the INTERVERTEBRAL DISC due to aging or structural damage, especially to the vertebral end-plates.

Fibrocartilage inner core of the intervertebral disc. Prolapsed or bulged nucleus pulposus leads to INTERVERTEBRAL DISC DISPLACEMENT while proliferation of cells in the nucleus pulposus is associated with INTERVERTEBRAL DISC DEGENERATION.

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