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Palliative Radiochemotherapy Against Palliative Surgery in Stage IV Rectal Cancer With Unresectable Metastases

2014-07-23 21:08:32 | BioPortfolio

Summary

Short course of palliative radiotherapy (5x5Gy)to the pelvis in patients with symptomatic rectal tumour with unresectable metastases may prevent palliative surgery with good palliative effect.The consolidating chemotherapy of Xelox may increase the efficacy of irradiation.

Description

Patients with symptomatic rectal cancer and unresectable metastases receive to the pelvis 25 Gy in 5 fractions of 5 Gy over 5 days and Xelox consolidating chemotherapy after one week. Investigators arbitrarily assumed that palliative radiotherapy to the pelvis can replace the immediate surgery if at least 30% of patients would avoid delayed surgery until the end of their life, or for at least 18 months in the case of long-term survival.

Study Design

Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Rectal Cancer

Intervention

short course of palliative radiotherapy

Location

M. Sklodowska-Curie Memorial Cancer Centre
Warsaw
Poland
02-781

Status

Recruiting

Source

Maria Sklodowska-Curie Memorial Cancer Center, Institute of Oncology

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:08:32-0400

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