Advertisement

Topics

Palliative Radiochemotherapy Against Palliative Surgery in Stage IV Rectal Cancer With Unresectable Metastases

2014-07-23 21:08:32 | BioPortfolio

Summary

Short course of palliative radiotherapy (5x5Gy)to the pelvis in patients with symptomatic rectal tumour with unresectable metastases may prevent palliative surgery with good palliative effect.The consolidating chemotherapy of Xelox may increase the efficacy of irradiation.

Description

Patients with symptomatic rectal cancer and unresectable metastases receive to the pelvis 25 Gy in 5 fractions of 5 Gy over 5 days and Xelox consolidating chemotherapy after one week. Investigators arbitrarily assumed that palliative radiotherapy to the pelvis can replace the immediate surgery if at least 30% of patients would avoid delayed surgery until the end of their life, or for at least 18 months in the case of long-term survival.

Study Design

Allocation: Non-Randomized, Control: Uncontrolled, Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Rectal Cancer

Intervention

short course of palliative radiotherapy

Location

M. Sklodowska-Curie Memorial Cancer Centre
Warsaw
Poland
02-781

Status

Recruiting

Source

Maria Sklodowska-Curie Memorial Cancer Center, Institute of Oncology

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:08:32-0400

Clinical Trials [1096 Associated Clinical Trials listed on BioPortfolio]

Palliative Short-Course Radiotherapy in Rectal Cancer

Radiotherapy (RT) is a potentially effective method in the treatment of symptoms of rectal carcinomas. Nevertheless, almost all the evidences about palliative RT in rectal cancer have been...

Dual REctcal Angiogenesis or MEK Inhibition radioTHERAPY Trial

To determine the maximum tolerated dose (MTD) of AZD6244 or AZD2171 when combined with pre-operative capecitabine and radiotherapy in patients with locally advanced rectal cancer.

Symptoms and Quality of Life (QoL) After Palliative Pelvic Radiation of Prostate and Rectal Cancers

The purpose of this study is to assess the effect of palliative pelvic radiation on symptoms and quality of life among patients with incurable prostate and rectal cancer.

Short Course Radiotherapy, Unresectable Rectal Cancer, Liver Metastasis

The purpose of this study is the increase of resection rate of primary cancer in rectal after short course radiotherapy without interrupt chemotherapy schedule during the period of chemoth...

The Randomised Study of Preoperative Radiotherapy With Consolidating Chemotherapy for Unresectable Rectal Cancer

The addition of Oxaliplatin to conventionally fractionated chemoradiation (FULV or capecitabine) is considered as standard in unresectable rectal cancer by the panel of experts. The Invest...

PubMed Articles [18357 Associated PubMed Articles listed on BioPortfolio]

Short Interval between Preoperative Short-Course Radiotherapy and Operation for Rectal Cancer Increases Anastomotic Leakage.

Short-course preoperative radiotherapy is indicated in patients with resectable rectal cancer to control local recurrence. Although no clear evidence is available, short-course radiotherapy with surge...

MMP7 Modulation by Short- and Long-term Radiotherapy in Patients with Rectal Cancer.

Matrix metalloproteinase 7 (MMP7) expression is highly associated with colorectal cancer and modulates tumour growth and invasion. Radiation injury induces inflammation with increases in MMP7 and in t...

Short- and long-term risks of cardiovascular disease following radiotherapy in rectal cancer in four randomized controlled trials and a population-based register.

A population-based cohort and four randomized trials enriched with long-term register data were used to clarify if radiotherapy in combination with rectal cancer surgery is associated with increased r...

Oncological strategies for locally advanced rectal cancer with synchronous liver metastases, interval strategy versus rectum first strategy: a comparison of short-term outcomes.

The goal of treatment for patients with synchronous liver metastases (SLM) from rectal cancer is to achieve a complete resection of both tumor locations. For patients with symptomatic locally advanced...

Rectal wall MRI radiomics in prostate cancer patients: Prediction of and correlation with early rectal toxicity.

To investigate MRI radiomic analysis to assess IMRT associated rectal wall changes and also for predicting radiotherapy induced rectal toxicity.

Medical and Biotech [MESH] Definitions

Radiotherapy given to augment some other form of treatment such as surgery or chemotherapy. Adjuvant radiotherapy is commonly used in the therapy of cancer and can be administered before or after the primary treatment.

Short-lived elementary particles found in cosmic radiation or produced from nuclear disintegration. Their mass is between that of protons and electrons and they can be negative, positive, or neutral. pi-Mesons (pions) are heavier than mu-mesons (muons) and are proposed for cancer radiotherapy because their capture and disintegration by matter produces powerful, but short-lived, secondary radiation.

Tumors or cancer of the RECTUM.

A nursing specialty concerned with care of patients facing serious or life-threatening illnesses. The goal of palliative nursing is to prevent and relieve suffering, and to support the best possible quality of life for patients and their families. Hospice nursing is palliative care for people in their final stages of life.

Physicians specializing in the treatment of cancer by RADIOTHERAPY.

More From BioPortfolio on "Palliative Radiochemotherapy Against Palliative Surgery in Stage IV Rectal Cancer With Unresectable Metastases"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topics

Palliative Care
Palliative care is the active holistic care of patients with advanced progressive illness. Management of pain and other symptoms and provision of psychological, social and spiritual support is paramount. The goal of palliative care is achievement of the ...

Cancer Disease
Cancer is not just one disease but many diseases. There are more than 100 different types of cancer. Most cancers are named for the organ or type of cell in which they start - for example, cancer that begins in the colon is called colon cancer; cancer th...


Searches Linking to this Trial