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Minimal Stimulation or Clomiphene Citrate in Treatment Polycystic Ovary Syndrome

2014-07-23 21:08:32 | BioPortfolio

Summary

The purpose of this study is to compare and determine the the efficacy of minimal stimulation and clomiphene citrate as the first-line treatment in infertile women with Polycystic Ovary Syndrome.

Description

All patients received 100 mg CC (Clomid®; Global Napi Pharmaceuticals, Cairo, Egypt) for 5 days starting from day 3 of spontaneous or induced menstruation. In group A (minimal stimulation), 2 vials of highly purified uFSH , 150 IU (Fostimon; IBSA, Lugano, Switzerland, 75 IU/vial) were given IM on cycle day 9. A total of 3 cycles was offered to each group.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment

Conditions

Polycystic Ovary Syndrome

Intervention

clomiphene citrate +highly purified uFSH, clomiphene citrate

Location

Mansoura University Hospitals,OB/GYN department
Mansoura
Dakahlia Governorate
Egypt

Status

Completed

Source

Mansoura University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:08:32-0400

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Medical and Biotech [MESH] Definitions

An enzyme that, in the presence of ATP and COENZYME A, catalyzes the cleavage of citrate to yield acetyl CoA, oxaloacetate, ADP, and ORTHOPHOSPHATE. This reaction represents an important step in fatty acid biosynthesis. This enzyme was formerly listed as EC 4.1.3.8.

Enzyme that catalyzes the first step of the tricarboxylic acid cycle (CITRIC ACID CYCLE). It catalyzes the reaction of oxaloacetate and acetyl CoA to form citrate and coenzyme A. This enzyme was formerly listed as EC 4.1.3.7.

The cis or (Z)-isomer of clomiphene.

The trans or (E)-isomer of clomiphene.

A triphenyl ethylene stilbene derivative which is an estrogen agonist or antagonist depending on the target tissue.

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