Advertisement

Topics

Treatment of Group A Beta Hemolytic Streptococcal Pharyngitis in Children in Low Resource Settings

2014-07-23 21:08:33 | BioPortfolio

Summary

The purpose of this study was to compare the microbiological effects of two different treatments: a single dose of intramuscular benzathine penicillin G (IM BPG) vs. a 10-day daily dose of amoxicillin for the treatment of GABHS pharyngitis in children in low resource settings. This study was a prospective multi-center randomized active control treatment trial. The trial is a non-inferiority equivalence trial, to determine if amoxicillin treatment is at least as effective as the currently given IM BPG treatment.

Study Design

Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Streptococcal Infections

Intervention

Penicillin G, Benzathine, Amoxicillin

Location

Federal University of Rio de Janeiro
Rio de Janeiro
Brazil

Status

Completed

Source

Johns Hopkins University

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-07-23T21:08:33-0400

Clinical Trials [489 Associated Clinical Trials listed on BioPortfolio]

One Dose Versus Three Weekly Doses of Benzathine Penicillin G for Patients With Early Syphilis

The purpose of this study is to observe the serological response to 1 or 3 weekly doses of benzathine penicillin G in patients with early syphilis.

Serological Response to Retreatment of Serofast Early Syphilis Cases With Benzathine Penicillin

A continuing challenge to determining the response to treatment of early syphilis (primary, secondary, early latent syphilis) is exemplified by the substantial proportion of patients who f...

Comparative Trial of Oral Penicillin Versus Cefuroxim for Treatment of Perianal Streptococcal Dermatitis

The goal of the study is to investigate, which of two antibiotic treatments - oral penicillin for 10 days or oral cefuroxim for 7 days - is more successful for patients (1-16 years of age)...

A Study of Benzathine Benzylpenicillin Intramuscular Injection in Japanese Healthy Subjects

This will be an open label study to investigate the pharmacokinetics (PK) and safety of a single intramuscular injection of penicillin G benzathine in Japanese healthy subjects.

Phase 4 Comparative Trial of Benzathine Penicillin G for Treatment of Early Syphilis in Subjects With or Without HIV Infection

This is a phase 4, randomized, open-label, multicenter trial to evaluate the efficacy of a single injected dose of BPG 2.4 MU (Arm 1) compared to three successive weekly injected doses of ...

PubMed Articles [3492 Associated PubMed Articles listed on BioPortfolio]

Natural experiment of syphilis treatment with doxycycline or benzathine penicillin in HIV-infected patients.

Although doxycycline is widely used as alternative to benzathine penicillin for the treatment of early and late latent syphilis, data on serological response following treatment with doxycycline among...

Direct oral amoxicillin challenge without preliminary skin testing in adult patients with allergy and at low risk with reported penicillin allergy.

Ten percent of hospitalized patients report penicillin allergy; however, recent studies indicate that ∼98% of these patients are not acutely hypersensitive. Unconfirmed penicillin allergy poses publ...

Streptococcal Infections and Exacerbations in PANDAS: A Systematic Review and Meta-Analysis.

The pediatric autoimmune neuropsychiatric disorders associated with streptococcal infection (PANDAS) hypothesis suggests an association between group A beta-hemolytic streptococcus (GABHS) infections ...

Determination of milk/plasma ratio and milk and plasma pharmacokinetics of amoxicillin after intramuscular administration in lactating cows.

This study was conducted to determine the passage ratio of amoxicillin into milk and its pharmacokinetics in milk and plasma after intramuscular administration. Five healthy dairy cows (Holstein, weig...

Streptococcal Serology in Acute Rheumatic Fever Patients: Findings from Two High-income, High Burden Settings.

Globally, there is wide variation in streptococcal titer upper limits of normal (ULN) for antistreptolysin O (ASO) and anti-deoxyribonuclease B (ADB) used as evidence of recent group A streptococcal (...

Medical and Biotech [MESH] Definitions

Semisynthetic antibiotic prepared by combining the sodium salt of penicillin G with N,N'-dibenzylethylenediamine.

A fixed-ratio combination of amoxicillin trihydrate (see AMOXICILLIN), an aminopenicillin, and potassium clavulanate (see CLAVULANIC ACID), a beta-lactamase inhibitor, used to treat a broad-spectrum of bacterial infections, especially resistant strains.

Vaccines or candidate vaccines used to prevent STREPTOCOCCAL INFECTIONS.

A broad-spectrum penicillin antibiotic used orally in the treatment of mild to moderate infections by susceptible gram-positive organisms.

Infections with bacteria of the genus STREPTOCOCCUS.

More From BioPortfolio on "Treatment of Group A Beta Hemolytic Streptococcal Pharyngitis in Children in Low Resource Settings"

Advertisement
Quick Search
Advertisement
Advertisement

 

Relevant Topic

Pediatrics
Pediatrics is the general medicine of childhood. Because of the developmental processes (psychological and physical) of childhood, the involvement of parents, and the social management of conditions at home and at school, pediatrics is a specialty. With ...


Searches Linking to this Trial