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Investigation of Gender Specificity of the Effects of Furosemide in Healthy Female and Male Volunteers

2014-08-27 03:12:28 | BioPortfolio

Summary

In this study the gender specificity of the effects of furosemide in female and male volunteers will be investigated. The healthy volunteers receive 1. furosemide and 2. aminohippurate sodium "PAH" as single dose. The main objective is gender-specific comparison of the pharmacokinetic parameters of furosemide in relation to the effect of furosemide (urinary excretion). Secondary objectives are the gender-specific comparison of renal and systemic PAH clearance with the clearance of furosemide and the influence of various genetic polymorphisms on the variability of furosemide pharmacokinetics.

Study Design

Allocation: Randomized, Control: Active Control, Endpoint Classification: Pharmacokinetics/Dynamics Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment

Conditions

Healthy Male and Female Volunteers

Intervention

Furosemide, aminohippurate sodium

Location

Clinical Trial Center North
Hamburg
Germany
20246

Status

Not yet recruiting

Source

Universitätsklinikum Hamburg-Eppendorf

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:28-0400

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