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Confocal Laser Endomicroscopy in Digestive Diseases

2014-08-27 03:12:29 | BioPortfolio

Summary

Confocal laser endomicroscopy (CLE) is a newly endoscopic device that enables microscopic view of the digestive tract. The purpose of this study is to determine if confocal laser endomicroscopy can improve detection of digestive disease include inflammation, dysplasia, and early cancer, and if confocal laser endomicroscopy has competitive advantage, compared with other device such as Narrow Band Imaging and Autofluoresecence Imaging.

Description

Advances in endoscopy have led to imagining of the details of digestive mucosa. Novel techniques such as Narrow Band Imaging (NBI) assisted magnification endoscopy, Auto Fluorescence Imaging (AFI) or confocal laser endomicroscopy could, however, improve the endoscopic detection.In this research we describe the combined use of these three techniques in patients with digestive disease.

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Conditions

Digestive System Diseases

Intervention

Confocal Laser Endomicroscopy (Pentax/Optiscan), Narrow Band Imaging/Auto Fluorescence Imaging (Olympus)

Location

China PLA General Hospital
Beijing
Bejing
China
100853

Status

Recruiting

Source

Chinese PLA General Hospital

Results (where available)

View Results

Links

Published on BioPortfolio: 2014-08-27T03:12:29-0400

Clinical Trials [1439 Associated Clinical Trials listed on BioPortfolio]

Confocal Laser Endomicroscopy (CLE) in Patients With Diarrhea

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Detection of Early Gastric Cancers Using Confocal Laser Endomicroscopy

The purpose of this study is to determine whether endomicroscopy can improve the detection of Early Gastric Cancers (EGC).

Clinical Trial for a Robotic Endomicroscopy to Better Define Resection Strategies Applied to Urology Surgery

This multicenter study aimed at assessing the feasibility of Probe-based Confocal Laser Endomicroscopy (pCLE) during Robotic-Assisted Radical Prostatectomy or Laparoscopic Radical Prostate...

PubMed Articles [9878 Associated PubMed Articles listed on BioPortfolio]

Bimodal Chromoendoscopy with Confocal Laser Endomicroscopy for the Detection of Early Esophageal Squamous Cell Neoplasms.

This study aimed to evaluate the diagnostic accuracy of dual-focus narrow-band imaging (dNBI) and Lugol'schromoendoscopy (LCE) combined with probe-based confocal laser endomicroscopy (pCLE) to screen ...

Multiphoton imaging provides a superior optical biopsy to that of confocal laser endomicroscopy imaging for colorectal lesions.

 Confocal laser endomicroscopy (CLE) requires fluorescence agents, the use of which leads to blurred images and low diagnostic accuracy owing to fluorescein leakage. We aimed to explore whether mult...

Use of probe-based confocal laser endomicroscopy for colon adenomas with topical application of acrinol drops.

Probe-based confocal laser endomicroscopy (pCLE) is a revolutionary modality that enables "optical biopsy" by enabling real-time imaging of the digestive tract . Application of a fluorescent agent is...

Deep learning-based detection of motion artifacts in probe-based confocal laser endomicroscopy images.

Probe-based confocal laser endomicroscopy (pCLE) is a subcellular in vivo imaging technique capable of producing images that enable diagnosis of malign structural modifications in epithelial tissue. I...

Probe-based confocal laser endomicroscopy of the gastric mucosa with curcumin dripping.

Probe-based confocal laser endomicroscopy (pCLE) is an innovative endoscopy that can visualize biological tissues to the cell level by intravenously administering a fluorescent dye. Fluorescein, a flu...

Medical and Biotech [MESH] Definitions

Imaging techniques that use illumination created with several optical interference filters by which the frequency ranges are spectrally narrowed and light scatter is greatly reduced. Thus the reflected photons reconstituting the images are from distinct depths (the surface and deeper layers) of the object being imaged.

A technique utilizing a laser coupled to a catheter which is used in the dilatation of occluded blood vessels. This includes laser thermal angioplasty where the laser energy heats up a metal tip, and direct laser angioplasty where the laser energy directly ablates the occlusion. One form of the latter approach uses an EXCIMER LASER which creates microscopically precise cuts without thermal injury. When laser angioplasty is performed in combination with balloon angioplasty it is called laser-assisted balloon angioplasty (ANGIOPLASTY, BALLOON, LASER-ASSISTED).

A light microscopic technique in which only a small spot is illuminated and observed at a time. An image is constructed through point-by-point scanning of the field in this manner. Light sources may be conventional or laser, and fluorescence or transmitted observations are possible.

The use of molecularly targeted imaging probes to localize and/or monitor biochemical and cellular processes via various imaging modalities that include RADIONUCLIDE IMAGING; ULTRASONOGRAPHY; MAGNETIC RESONANCE IMAGING; fluorescence imaging; and MICROSCOPY.

Techniques using laser energy in combination with a balloon catheter to perform angioplasty. These procedures can take several forms including: 1, laser fiber delivering the energy while the inflated balloon centers the fiber and occludes the blood flow; 2, balloon angioplasty immediately following laser angioplasty; or 3, laser energy transmitted through angioplasty balloons that contain an internal fiber.

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