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Bioavailability and Food Effect Study of TKI258 (CSF Capsule vs. FMI Tablet) in Adult Patients With Advanced Solid Tumors

2014-10-22 21:49:46 | BioPortfolio

Published on BioPortfolio: 2014-10-22T21:49:46-0400

Clinical Trials [33 Associated Clinical Trials listed on BioPortfolio]

Bioavailability and Food Effect Study of TKI258 (CSF Capsules vs. FMI Capsules)in Adult Patients With Advanced Solid Tumors

This study will evaluate the relative bioavailability of 2 oral formulations of TKI258, and the effect of food on the bioavailability of TKI258, in adult patients with advanced solid tumor

Phase II Study of TKI258 in Advanced Urothelial Carcinoma

This study will evaluate the efficacy of TKI258 in patients with advanced urothelial cancer

Safety of TKI258 in Advanced/Metastatic Melanoma Subjects

This study is an open-label, dose-escalating study to delineate the safety, pharmacokinetics (PK), and pharmacodynamics (PD) of TKI258. Pharmacokinetics and pharmacodynamics will be perfo...

Dovitinib in Adenoid Cystic Carcinoma

The purpose of this phase II study of TKI258 (Dovitinib) in adenoid cystic carcinoma is to evaluate the efficacy of TKI258 (Dovitinib).

Safety and Efficacy of TKI258 in Relapsed or Refractory Multiple Myeloma Patients, Who Are With or Without t(4;14) Chromosomal Translocation

This study will evaluate safety and efficacy of TKI258 in patients with relapsed or refractory multiple myeloma

PubMed Articles [332 Associated PubMed Articles listed on BioPortfolio]

Mucinous cystic neoplasm of the liver with biliary communication: an exception to the current classification.

Cystic neoplasms of the liver are rare tumours. According to the recent WHO classification, they are classified into mucinous cystic neoplasm and intraductal papillary neoplasm based on the presence o...

An Analysis of Blastic Plasmacytoid Dendritic Cell Neoplasm with Translocations Involving the MYC Locus Identifies t(6;8)(p21;q24) as a Recurrent Cytogenetic Abnormality.

Blastic plasmacytoid dendritic cell neoplasm (BPDCN) is an aggressive neoplasm with leukemic features and frequent skin involvement. Translocations involving the MYC locus have been recently identifie...

Incidence and survival of therapy related myeloid neoplasm in United States.

Therapy related myeloid neoplasm (t-MN) is an emerging challenge in the current era. However, real world data on its incidence and survival at the population level remains sparse.

"Reversible" myelodysplastic syndrome or ineffectual clonal haematopoiesis? - add(6p) myeloid neoplasm with a spontaneous cytogenetic remission.

Cytotoxic chemotherapy has inherent mutagenic potential and alters the bone marrow microenvironment after therapy. In some cases, this potentiates expansion of an aberrant clone and may lead to a ther...

Risk of second primary neoplasm and mortality in childhood cancer survivors based on a national registry database.

Although overall childhood cancer survival has improved, survivors may still have an elevated risk for second primary neoplasm (SPN) and excess mortality. The aim of the current study was to estimate ...

Medical and Biotech [MESH] Definitions

Abnormal growths of tissue that follow a previous neoplasm but are not metastases of the latter. The second neoplasm may have the same or different histological type and can occur in the same or different organs as the previous neoplasm but in all cases arises from an independent oncogenic event. The development of the second neoplasm may or may not be related to the treatment for the previous neoplasm since genetic risk or predisposing factors may actually be the cause.

The local recurrence of a neoplasm following treatment. It arises from microscopic cells of the original neoplasm that have escaped therapeutic intervention and later become clinically visible at the original site.

The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.

Disappearance of a neoplasm or neoplastic state without the intervention of therapy.

Methods which attempt to express in replicable terms the extent of the neoplasm in the patient.

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